2. Cell Cycle/DNA Damage Anti-infection
  3. DNA/RNA Synthesis Influenza Virus
  4. RdRP-IN-4

RdRP-IN-4 (compound 11q), an aryl benzoyl hydrazide analog, is an orally active influenza A virus RNA-dependent RNA polymerase (RdRp) inhibitor by interacting with the PB1 subunit. RdRP-IN-4 exhibits potent inhibitory activity against the avian H5N1 flu strain with an EC50 of 18 nM in MDCK cells. RdRP-IN-4 displays excellent potency against the the H1N1 (A/PR/8/34) Flu A strain and Flu B strain (B/Lee/1940) with EC50 values of 53 nM and 20 nM, respectively. RdRP-IN-4 significantly inhibits the expression level of viral nucleoprotein (NP) in a dose-dependent manner. RdRP-IN-4 exhibits significant antiviral activity in infected mice.

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RdRP-IN-4

RdRP-IN-4 Estructura química

No. CAS : 3035088-22-0

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RdRP-IN-4 Related Antibodies

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Descripciòn

RdRP-IN-4 (compound 11q), an aryl benzoyl hydrazide analog, is an orally active influenza A virus RNA-dependent RNA polymerase (RdRp) inhibitor by interacting with the PB1 subunit. RdRP-IN-4 exhibits potent inhibitory activity against the avian H5N1 flu strain with an EC50 of 18 nM in MDCK cells. RdRP-IN-4 displays excellent potency against the the H1N1 (A/PR/8/34) Flu A strain and Flu B strain (B/Lee/1940) with EC50 values of 53 nM and 20 nM, respectively. RdRP-IN-4 significantly inhibits the expression level of viral nucleoprotein (NP) in a dose-dependent manner. RdRP-IN-4 exhibits significant antiviral activity in infected mice[1].

IC50 & Target

RNA Polymerase

 

Cellular Effect
Cell Line Type Value Description References
MDCK CC50
> 100 μM
Compound: 11q
Cytotoxicity against dog MDCK cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
Cytotoxicity against dog MDCK cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
[PMID: 35212527]
Peso molecular

455.14

Fòrmula

C17H17Br2N3O2
No. CAS
SMILES

O=C(C1=CC=C(C=C1)N2CCOCC2)NNC3=C(C=CC=C3Br)Br
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
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Referencias
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RdRP-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RdRP-IN-43035088-22-0DNA/RNA SynthesisInfluenza Virusaryl benzoyl hydrazideorallyRdRpH5N1flu strainMDCKH1N1Flu Bviral nucleoproteinPB1antiviralInhibitorinhibitorinhibit

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Nombre del producto:
RdRP-IN-4
Cat. No.:
HY-144668
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