AACS Protein, Human (sf9, His)

AACS proteins play a key role in cellular metabolism by converting acetoacetate in the cytoplasm into acetoacetyl-CoA (by similarity). As a ketone body utilizing enzyme, AACS helps synthesize essential cellular components including cholesterol and fatty acids (by similarity). AACS Protein, Human (sf9, His) is the recombinant human-derived AACS protein, expressed by Sf9 insect cells , with N-His labeled tag.

The AACS protein is instrumental in cellular metabolism as it converts acetoacetate to acetoacetyl-CoA in the cytosol, showcasing its involvement in ketone body utilization. This enzymatic activity is integral to the synthesis of cholesterol and fatty acids, underscoring AACS's pivotal role in lipid metabolism. As a key player in the conversion of acetoacetate, a ketone body, into acetoacetyl-CoA, AACS contributes to the cellular processes that are crucial for the synthesis of essential lipids, emphasizing its significance in maintaining lipid homeostasis and supporting biosynthetic pathways for cholesterol and fatty acids (

Human

Sf9 insect cells

N-His

Q86V21-1 (M1-F672)

65985  [NCBI]

Full Length of Isoform-1

MSKEERPGREEILECQVMWEPDSKKNTQMDRFRAAVGAACGLALESYDDLYHWSVESYSDFWAEFWKFSGIVFSRVYDEVVDTSKGIADVPEWFKGSRLNYAENLLRHKENDRVALYIAREGKEEIVKVTFEELRQEVALFAAAMRKMGVKKGDRVVGYLPNSEHAVEAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHNHMEKLQQVVKGLPDLKKVVVIPYVSSRENIDLSKIPNSVFLDDFLATGTSEQAPQLEFEQLPFSHPLFIMFSSGTTGAPKCMVHSAGGTLIQHLKEHLLHGNMTSSDILLCYTTVGWMMWNWMVSLLATGAAMVLYDGSPLVPTPNVLWDLVDRIGITVLVTGAKWLSVLEEKAMKPVETHSLQMLHTILSTGSPLKAQSYEYVYRCIKSSILLGSISGGTDIISCFMGHNFSLPVYKGEIQARNLGMAVEAWNEEGKAVWGESGELVCTKPIPCQPTHFWNDENGNKYRKAYFSKFPGIWAHGDYCRINPKTGGIVMLGRSDGTLNPNGVRFGSSEIYNIVESFEEVEDSLCVPQYNKYREERVILFLKMASGHAFQPDLVKRIRDAIRMGLSARHVPSLILETKGIPYTLNGKKVEVAVKQIIAGKAVEQGGAFSNPETLDLYRDIPELQGF

Approximately 60 kDa,based on SDS-PAGE under reducing conditions.

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.