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CADM4/IGSF4C Protein, Mouse (HEK293, His)

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CADM4/IGSF4C Protein, vital for cell-cell adhesion, has calcium- and magnesium-independent activity. Its adhesive role suggests a function in tissue integrity. Additionally, it may act as a tumor suppressor, inhibiting cellular proliferation and tumorigenesis. As a monomer and homodimer, CADM4/IGSF4C Protein dynamically interacts, coordinating adhesion and potential tumor suppression. CADM4/IGSF4C Protein, Mouse (HEK293, His) is the recombinant mouse-derived CADM4/IGSF4C protein, expressed by HEK293 , with C-His labeled tag.

For research use only. We do not sell to patients.
  • Species: Mouse
  • Source: HEK293
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
  • CADM4/IGSF4C Protein, Mouse (HEK293, His) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
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Biological Activity

Description

CADM4/IGSF4C Protein, vital for cell-cell adhesion, has calcium- and magnesium-independent activity. Its adhesive role suggests a function in tissue integrity. Additionally, it may act as a tumor suppressor, inhibiting cellular proliferation and tumorigenesis. As a monomer and homodimer, CADM4/IGSF4C Protein dynamically interacts, coordinating adhesion and potential tumor suppression. CADM4/IGSF4C Protein, Mouse (HEK293, His) is the recombinant mouse-derived CADM4/IGSF4C protein, expressed by HEK293 , with C-His labeled tag.

Background

CADM4/IGSF4C Protein plays a crucial role in cell-cell adhesion, exhibiting calcium- and magnesium-independent activity. Its involvement in mediating adhesive interactions between cells suggests a potential role in maintaining tissue integrity. Beyond its adhesive functions, CADM4/IGSF4C Protein may possess tumor-suppressor activity, implicating its potential significance in regulating cellular proliferation and inhibiting tumorigenesis. As a monomer and homodimer, CADM4/IGSF4C Protein likely participates in dynamic cellular interactions, contributing to the coordination of various physiological processes related to adhesion and potential tumor suppression.

Verified Bioactivity

Measured by its ability to inhibit the proliferation of A549 cells. The ED50 for this effect is 0.9491 μg/mL, corresponding to a specific activity is 1.054×103 units/mg.

Technical Parameters

  • Species Mouse
  • Source HEK293
  • Tag C-6*His
  • Accession

    Q8R464 (P21-A324)

  • Gene ID
    260299  [NCBI]
  • Molecular Construction
    • N-term
    • CADM4 (P21-A324)
      Accession # Q8R464
    • His
    • C-term
  • Protein Length

    Extracellular Domain

  • Synonyms

    CADM4; TSLC1-Like Protein 2; Prev. IGSF4C; NECL4; TSLL2; Immunoglobulin Superfamily, Member 4C; SynCAM4; TSLC1-Like 2; Necl-4; NECL-4; Immunoglobulin Superfamily Member 4C; IgSF4C; Nectin-Like Protein 4; Cell Adhesion Molecule 4; Nectin-Like 4

  • AA Sequence

    PGTGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAAVLRWYRDRKELKGVSSGQENGKVWSVASTVRFRVDRKDDGGIVICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEAANKHGHARALYVLVVYDPGAVVEAQTSVPYA

  • Molecular Weight

    Approximately 50-60 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

  • Glycosylation

    Yes

  • Purity

    ≥ 95%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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