CANT1 Protein, Human (HEK293, Fc)
CANT1 is a calcium-dependent nucleotidase that shows a clear preference for UDP, and the order of its enzymatic activity is UDP > GDP > UTP > GTP. It is worth noting that it has little activity on ADP and even less activity on ATP, but it does not hydrolyze AMP and GMP. CANT1 Protein, Human (HEK293, Fc) is the recombinant human-derived CANT1 protein, expressed by HEK293 , with N-hFc labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
CANT1 is a calcium-dependent nucleotidase that shows a clear preference for UDP, and the order of its enzymatic activity is UDP > GDP > UTP > GTP. It is worth noting that it has little activity on ADP and even less activity on ATP, but it does not hydrolyze AMP and GMP. CANT1 Protein, Human (HEK293, Fc) is the recombinant human-derived CANT1 protein, expressed by HEK293 , with N-hFc labeled tag.
Background
CANT1, a calcium-dependent nucleotidase, exhibits a strong preference for UDP as its substrate, with the order of activity being UDP > GDP > UTP > GTP. Notably, it demonstrates very low activity towards ADP and even lower activity towards ATP, while it does not hydrolyze AMP and GMP. This enzymatic profile suggests a specific role in nucleotide metabolism. CANT1 is implicated in proteoglycan synthesis, indicating its involvement in processes related to the modification and regulation of these important macromolecules. The calcium-dependent nature of CANT1 highlights its regulation by intracellular calcium levels, adding an additional layer of complexity to its enzymatic function and potential cellular roles.
Technical Parameters
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Species Human
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Source HEK293
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Tag N-hFc
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Accession
Q8WVQ1-1 (G80-I401)
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Molecular Construction
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N-term
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hFc
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CANT1 (G80-I401)
Accession # Q8WVQ1-1 -
C-term
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Protein Length
Partial
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Synonyms
CANT1; Apyrase Homolog; Calcium Activated Nucleotidase 1; Micromelic Dwarfism With Vertebral And Metaphyseal Abnormalities And Advanced Carpotarsal Ossification; SCAN-1; Ca2+-Dependent Endoplasmic Reticulum Nucleoside Diphosphatase; SHAPY; Soluble Calcium
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AA Sequence
GQAPANWYNDTYPLSPPQRTPAGIRYRIAVIADLDTESRAQEENTWFSYLKKGYLTLSDSGDKVAVEWDKDHGVLESHLAEKGRGMELSDLIVFNGKLYSVDDRTGVVYQIEGSKAVPWVILSDGDGTVEKGFKAEWLAVKDERLYVGGLGKEWTTTTGDVVNENPEWVKVVGYKGSVDHENWVSNYNALRAAAGIQPPGYLIHESACWSDTLQRWFFLPRRASQERYSEKDDERKGANLLLSASPDFGDIAVSHVGAVVPTHGFSSFKFIPNTDDQIIVALKSEEDSGRVASYIMAFTLDGRFLLPETKIGSVKYEGIEFI
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Predicted Molecular Mass
64.3 kDa
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Molecular Weight
Approximately 65 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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