CCNT1 Protein, Human
CCNT1 Protein, Human is the recombinant human-derived CCNT1, expressed by E. coli , with tag Free labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
CCNT1 Protein, Human is the recombinant human-derived CCNT1, expressed by E. coli , with tag Free labeled tag.
Cyclin T1 is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also known as positive transcription elongation factor B (P-TEFb). This complex facilitates the transition from abortive to productive elongation by phosphorylating the C-terminal domain (CTD) of the large subunit of RNA polymerase II (RNA Pol II). Cyclin T1 activates the protein kinase activity of CDK9 by mediating the formation of liquid-liquid phase separation (LLPS), enhancing the binding of P-TEFb to the CTD of RNA Pol II. During HIV or SIV infections, Cyclin T1 binds to the transactivation domain of the viral transcriptional activator Tat, increasing Tat's affinity for the transactivating response RNA element (TAR RNA). It serves as an essential cofactor for Tat, promoting RNA Pol II activation and enabling the transcription of viral genes.
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
O60563-1 (M1-R259)
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Gene ID904
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Protein Length
Partial
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Synonyms
CCNT1; Cyclin-T1; Prev. HIVE1; Cyclin C-Related Protein; CYCT1; MLLT10/CCNT1 Fusion; CCNT; Cyclin-T; Human Immunodeficiency Virus Type 1 (HIV-1) Expression (Elevated) 1; CycT1; Cyclin T1; CDK9-Associated C-Type Protein
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AA Sequence
MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWR
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Predicted Molecular Mass
30.3 kDa
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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