CD162/PSGL-1 Protein, Cynomolgus (HEK293, His)

As a member of the selectin family, CD162/PSGL-1 is mainly expressed in some immune or inflammatory cells. CD162/PSGL-1 deficiency affects myeloid differentiation and lymphocyte maturation and therefore has important implications for cell differentiation. CD162/PSGL-1 can be used as an immune checkpoint modulator and may be a new target for cancer therapy. CD162/PSGL-1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD162/PSGL-1 protein, expressed by HEK293 , with C-His labeled tag.

Selectin P ligand, also known as SELPLG or CD162, is a high-affinity antagonistic receptor for P-selectin on myeloid cells and stimulated T lymphocytes. SELPLG, as a member of the selectin family, is mainly expressed in some immune or inflammatory cells. SELPLG deficiency affects myeloid differentiation and lymphocyte maturation and therefore has important implications for cell differentiation. SELPLG can be used as an immune checkpoint modulator and maybe a new target for cancer therapy^[1][2].

Cynomolgus

HEK293

C-8*His

A0A7N9CVJ8 (L34-C356)

102142477

Partial

LQLWDTRADEAKKALGPLLARNRRQATEYEYLDYDFLPETEPPEILSNSTNTTSLTGPGNPESTTVEPAARHSTGLDTGGSVTELTMELANMGTLSMDSAAMEVQTTHPAATEAQTTQPAAMEAQTTQPAATEAQTTPLAATEALTTQLVATEAQTTPLAATEVQTTQLATTEAQTTPLAATEAQTTPPAATETQSAPPAATEAQTTPPAATEVQTTQPIATEAQTTAPASTEAQTTPPATTEAQTTQPIATEAQTTPLAATEALSTEPNATEALSMEPTTKKGLFIPFSVSSVTHKGIPMAASNLSINHPVGSPDHISVKQC

72-82 kDa

≥ 95%, as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.