CD162/PSGL-1 Protein, Cynomolgus (HEK293, His)
Based on 1 Customer Validation
As a member of the selectin family, CD162/PSGL-1 is mainly expressed in some immune or inflammatory cells. CD162/PSGL-1 deficiency affects myeloid differentiation and lymphocyte maturation and therefore has important implications for cell differentiation. CD162/PSGL-1 can be used as an immune checkpoint modulator and may be a new target for cancer therapy. CD162/PSGL-1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD162/PSGL-1 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Cynomolgus
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
As a member of the selectin family, CD162/PSGL-1 is mainly expressed in some immune or inflammatory cells. CD162/PSGL-1 deficiency affects myeloid differentiation and lymphocyte maturation and therefore has important implications for cell differentiation. CD162/PSGL-1 can be used as an immune checkpoint modulator and may be a new target for cancer therapy. CD162/PSGL-1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD162/PSGL-1 protein, expressed by HEK293 , with C-His labeled tag.
Background
Selectin P ligand, also known as SELPLG or CD162, is a high-affinity antagonistic receptor for P-selectin on myeloid cells and stimulated T lymphocytes. SELPLG, as a member of the selectin family, is mainly expressed in some immune or inflammatory cells. SELPLG deficiency affects myeloid differentiation and lymphocyte maturation and therefore has important implications for cell differentiation. SELPLG can be used as an immune checkpoint modulator and maybe a new target for cancer therapy[1][2].
Technical Parameters
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Species Cynomolgus
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Source HEK293
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Tag C-8*His
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Accession
A0A7N9CVJ8 (L34-C356)
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Gene ID102142477
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Molecular Construction
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N-term
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PSGL-1 (L34-C356)
Accession # A0A7N9CVJ8 -
8*His
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C-term
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Protein Length
Partial
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Synonyms
SELPLG; Cutaneous Lymphocyte-Associated Associated Antigen; Selectin P Ligand; CD162 Antigen; PSGL-1; PSGL1; CD162; CLA; P-Selectin Glycoprotein Ligand 1
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AA Sequence
LQLWDTRADEAKKALGPLLARNRRQATEYEYLDYDFLPETEPPEILSNSTNTTSLTGPGNPESTTVEPAARHSTGLDTGGSVTELTMELANMGTLSMDSAAMEVQTTHPAATEAQTTQPAAMEAQTTQPAATEAQTTPLAATEALTTQLVATEAQTTPLAATEVQTTQLATTEAQTTPLAATEAQTTPPAATETQSAPPAATEAQTTPPAATEVQTTQPIATEAQTTAPASTEAQTTPPATTEAQTTQPIATEAQTTPLAATEALSTEPNATEALSMEPTTKKGLFIPFSVSSVTHKGIPMAASNLSINHPVGSPDHISVKQC
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Predicted Molecular Mass
34.6 kDa
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Molecular Weight
Approximately 75-105 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (237 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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