CEACAM6 Protein, Cynomolgus (HEK293, His-Avi)
CEACAM6 Protein, Cynomolgus (HEK293, His-Avi) is the recombinant cynomolgus-derived CEACAM6 protein, expressed by HEK293, with C-Avi & C-His tag.
- Species: Cynomolgus
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
CEACAM6 Protein, Cynomolgus (HEK293, His-Avi) is the recombinant cynomolgus-derived CEACAM6 protein, expressed by HEK293, with C-Avi & C-His tag.
Background
CEACAM6 protein, a cell surface glycoprotein, assumes a pivotal role in cell adhesion and tumor progression. Interactions occur in a calcium- and fibronectin-independent manner, mediating both homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules like CEACAM5 and CEACAM8. Particularly, heterophilic interaction with CEACAM8 takes place in activated neutrophils, influencing neutrophil adhesion to cytokine-activated endothelial cells. In the context of tumor progression, CEACAM6 operates as an oncogene by positively regulating cell migration, adhesion to endothelial cells, and invasion. Additionally, it contributes to the metastatic cascade by inducing resistance to anoikis in pancreatic adenocarcinoma and colorectal carcinoma cells. CEACAM6 forms homodimers, engaging in homodimerization via its Ig-like V-type domain, and also forms heterodimers with CEACAM8 through their respective Ig-like V-type domains, highlighting its multifaceted role in cell adhesion and cancer-related processes.
Technical Parameters
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Species Cynomolgus
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Source HEK293
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Tag C-Avi;C-His
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Accession
XP_005589488.3 (Q35-G320)
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Gene ID135964351
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Molecular Construction
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N-term
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CEACAM6 (Q35-G320)
Accession # XP_005589488.3 -
Avi
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His
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C-term
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Protein Length
Partial
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Synonyms
CEACAM6; Cell Adhesion Molecule CEACAM6; Prev. NCA; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6; NCA-50/90; Non-Specific Crossreacting Antigen; CD66c; Cluster Of Differentiation 66c; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6
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AA Sequence
QLTIESRPFNVAEGKEVLLLAHNLPQNLIGFNWYKGERVDAKRLIVAYVIGTQQTTPGPAHSGREMIYSNASLLIQNVTQNDTGSYTLQVIKGDLVNEEATGRFWVYPELPKPYITSNNSNPVEDKDAVDFTCEPDIHSTTYLWWVNGQSLPVSPRLQLSNGNRTLTLLSVKRNDAGAYECEIQNPVSANFSDPVILNVLYGPDVPTISPSNSNYRPGENLNLSCHAASNPTAQYSWFVNGTFQQSTQELFIPNITVNNSGSYMCQAYNSATGLNRTTVMMITVSG
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Predicted Molecular Mass
34.5 kDa
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Molecular Weight
Approximately 60-80 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by Bis-Tris PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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