CTLA-4 Protein, Guinea pig (P.pastoris, His)

CTLA-4 protein, a potent inhibitory receptor, plays a crucial role in suppressing T-cell responses by binding strongly to its ligands CD80 and CD86, surpassing the affinity of CD28. This heightened affinity allows CTLA-4 to act as a major negative regulator, maintaining immune homeostasis and preventing excessive T-cell activation. The balance between CTLA-4 and its ligands is pivotal for immune regulation. CTLA-4 Protein, Guinea pig (P.pastoris, His) is the recombinant CTLA-4 protein, expressed by P. pastoris , with C-6*His labeled tag. The total length of CTLA-4 Protein, Guinea pig (P.pastoris, His) is 125 a.a., with molecular weight of ~18.0 kDa.

CTLA-4 protein functions as a prominent inhibitory receptor, playing a crucial role in dampening T-cell responses. Its inhibitory action stems from the remarkably strong affinity CTLA-4 exhibits for its natural B7 family ligands, CD80 and CD86, surpassing the affinity of their counterpart stimulatory coreceptor, CD28. By virtue of this heightened affinity, CTLA-4 serves as a major negative regulator in the intricate orchestration of T-cell activation and immune responses. The nuanced balance between stimulatory and inhibitory signals mediated by CTLA-4 and its ligands is pivotal for maintaining immune homeostasis and preventing excessive or aberrant T-cell activation.

The ED₅₀ as determined by its ability to bind Mouse B7-1 in functional ELISA is less than 0.4 μg/mL.

Others

P. pastoris

C-6*His

H0VUB1 (A37-D161)

100725760  [NCBI]

AMHVAQPAVVLASSRGVASFECEYASSHNANEVRVTVLQQVASRTTEICAATYTVERELAFPEDSACAGTSSGTRVNLTIQGLRAADTGLYICKVELMYPPPYFVGTGNGTQIYVIDPEPCPDSD

Approximately 18.0 kDa

• 
  Greater than 90% as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.2 μm filter solution of 1xPBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.