DBNL Protein, Human (HEK293, His, Strep)
DBNL Protein, Human (HEK293, His, Strep) is the recombinant human-derived DBNL, expressed by HEK293 , with Strep, His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
DBNL Protein, Human (HEK293, His, Strep) is the recombinant human-derived DBNL, expressed by HEK293 , with Strep, His labeled tag.
Background
DBNL is an adapter protein that binds F-actin and DNM1, playing a role in receptor-mediated endocytosis. It regulates actin cytoskeleton reorganization, cell projection formation (e.g., neurites), neuron morphogenesis, and synapse formation via interactions with WASL and COBL. DBNL does not bind G-actin or promote actin polymerization independently. It may act as a common effector in leukocyte antigen receptor-signaling pathways (By similarity) and serves as a key component of the immunological synapse, linking TCRs to the actin cytoskeleton to modulate T-cell activation, gene induction, and endocytic processes.
Technical Parameters
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Species Human
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Source HEK293
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Tag Strep;His
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Accession
Q9UJU6-1 (M1-E430)
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Gene ID28988
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Protein Length
Full Length of Isoform-1
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Synonyms
DBNL; Drebrin-Like Protein; Drebrin Like; Cervical SH3P7; HIP-55; Drebrin-F; SH3P7; CDNA FLJ59450, Highly Similar To Drebrin-Like Protein; HPK1-Interacting Protein Of 55 KDa; Src Homology 3 Domain-Containing Protein HIP-55; ABP1; Drebrin-Like; Cervical Mu
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AA Sequence
MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSGKVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAEEDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE
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Predicted Molecular Mass
51.4 kDa
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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