DCAF7 Protein, Human (sf9)
The DCAF7 protein occupies a central position in craniofacial development and is critical for the EDN1 pathway and maxillary formation. Its nuanced involvement suggests different requirements for EDN1 function in the first and second arches. DCAF7 Protein, Human (sf9) is the recombinant human-derived DCAF7 protein, expressed by sf9 insect cells , with tag free.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The DCAF7 protein occupies a central position in craniofacial development and is critical for the EDN1 pathway and maxillary formation. Its nuanced involvement suggests different requirements for EDN1 function in the first and second arches. DCAF7 Protein, Human (sf9) is the recombinant human-derived DCAF7 protein, expressed by sf9 insect cells , with tag free.
Background
DCAF7 protein takes center stage in craniofacial development, playing a pivotal role upstream of the EDN1 pathway and contributing significantly to the formation of the upper jaw equivalent, the palatoquadrate. Its nuanced involvement is highlighted by distinct activity requirements for EDN1 pathway function in the first and second arches. Additionally, DCAF7 forms an intricate partnership with DIAPH1, exerting control over GLI1 transcriptional activity. Beyond craniofacial development, this protein emerges as a potential player in both normal and disease-related skin development. Notably, it may function as a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex, shedding light on its engagement in protein modification processes, particularly protein ubiquitination.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag Tag Free
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Accession
P61962 (S2-V342)
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Gene ID10238
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Molecular Construction
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N-term
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DCAF7 (S2-V342)
Accession # P61962 -
C-term
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Protein Length
Full Length
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Synonyms
DCAF7; WD Repeat-Containing Protein 68; Prev. WDR68; Seven-WD-Repeat Protein Of The AN11 Family-1; HAN11; Human Anthocyanin; WD Repeat-Containing Protein An11 Homolog; WD Repeat Domain 68; DDB1- And CUL4-Associated Factor 7; AN11; DDB1 And CUL4 Associated
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AA Sequence
SLHGKRKEIYKYEAPWTVYAMNWSVRPDKRFRLALGSFVEEYNNKVQLVGLDEESSEFICRNTFDHPYPTTKLMWIPDTKGVYPDLLATSGDYLRVWRVGETETRLECLLNNNKNSDFCAPLTSFDWNEVDPYLLGTSSIDTTCTIWGLETGQVLGRVNLVSGHVKTQLIAHDKEVYDIAFSRAGGGRDMFASVGADGSVRMFDLRHLEHSTIIYEDPQHHPLLRLCWNKQDPNYLATMAMDGMEVVILDVRVPCTPVARLNNHRACVNGIAWAPHSSCHICTAADDHQALIWDIQQMPRAIEDPILAYTAEGEINNVQWASTQPDWIAICYNNCLEILRV
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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