DCAF7 Protein, Human (Sf9)

The DCAF7 protein occupies a central position in craniofacial development and is critical for the EDN1 pathway and maxillary formation. Its nuanced involvement suggests different requirements for EDN1 function in the first and second arches. DCAF7 Protein, Human (Sf9) is the recombinant human-derived DCAF7 protein, expressed by Sf9 insect cells , with tag free. The total length of DCAF7 Protein, Human (Sf9) is 341 a.a., .

DCAF7 protein takes center stage in craniofacial development, playing a pivotal role upstream of the EDN1 pathway and contributing significantly to the formation of the upper jaw equivalent, the palatoquadrate. Its nuanced involvement is highlighted by distinct activity requirements for EDN1 pathway function in the first and second arches. Additionally, DCAF7 forms an intricate partnership with DIAPH1, exerting control over GLI1 transcriptional activity. Beyond craniofacial development, this protein emerges as a potential player in both normal and disease-related skin development. Notably, it may function as a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex, shedding light on its engagement in protein modification processes, particularly protein ubiquitination.

Human

Sf9 insect cells

Tag Free

P61962 (S2-V342)

10238

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.