DSC3/Desmocollin-3 Protein, Mouse (Cell-Free, His)

DSC3 is a component of intercellular desmosome junctions and plays a key role in orchestrating complex interactions between plaque proteins and intermediate filaments, thereby promoting strong cell-to-cell adhesion. In addition to its adhesive function, DSC3 emerges as a potential contributor to epidermal cell localization, particularly in the context of cell stratification. DSC3/Desmocollin-3 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived DSC3/Desmocollin-3 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of DSC3/Desmocollin-3 Protein, Mouse (Cell-Free, His) is 761 a.a., with molecular weight of 86.3 kDa.

Desmocollin-3 (DSC3) is a vital component of intercellular desmosome junctions, essential for mediating cell-cell adhesion. Operating within these junctions, DSC3 facilitates the interaction between plaque proteins and intermediate filaments, playing a crucial role in the structural integrity and stability of tissues. Notably, DSC3 may contribute to the positioning and stratification of epidermal cells by mediating differential adhesiveness between cells expressing different isoforms. This suggests its involvement in the regulation of cell arrangements within the epidermal layer. The multifaceted functions of DSC3 underscore its significance in cellular adhesion processes and tissue organization, emphasizing its role in maintaining the proper structure and function of various tissues. (

Mouse

E. coli Cell-free

N-10*His

P55850 (R136-R896)

13507

RWAPIPCSMQENSLGPFPLFLQQVQSDAAQNYTVFYSISGRGADQEPLNWFFIERDTGNLYCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIKIEDENDNYPLFTEAIYAFEVPEGSRLGTVVGTVCATDKDEPDTMHTRLKYSILEQTPPSPGLFSVHPDTGVITTVSHYMDREVVDKYKLIMKVQDMNGQFFGLISTSTCIITVQDSNDNAPTFRQNTYETAVEENTYNVEILRIPVDDKDMINTANWKANFTILKGNENGWFKITTDPVTNEGVLCVVKPLDYEENRQVTLEIGVNNEAPFIKDVANRIPTMNRAMVTVHVKDQNEGPECKPPEQYVRIKENSAVGSKINGYKAYDPETKNSNGLRYKKLQDPKDWVSIEEVSGLLTISKTLDREIMAPRNDMYNITVMAIDQEGKSCTGTLAVNIEDVNDNAPEIIQDYIVICKPKMGYTDISAVDPDEPIHGPPFQFNLANTSPEVNRIWTLNQVNDTAARLSYQKTADVQIYNVPVTVKDRAGQSATKILRVNLCDCTHPSQCPLRSRSAGITLGKWAILAILLGIALLFSVLLTLVCGVVTARKGKHFPEDLAQQNLIISNTEAPGDDRVCSANGFTTHTANNSSQGFCGTMGSGMRNGGQETIEMMKGHQTLDSCRVAGHHHTLDSGRGGHMDTDNCRYTYSEWHSFTQPRLGEKLHVCNQNEDHIPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEEGLDFLNNLEPKFLTLAETCTKR

86.3 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.