DSC3/Desmocollin-3 Protein, Mouse (Cell-Free, His)
DSC3 is a component of intercellular desmosome junctions and plays a key role in orchestrating complex interactions between plaque proteins and intermediate filaments, thereby promoting strong cell-to-cell adhesion. In addition to its adhesive function, DSC3 emerges as a potential contributor to epidermal cell localization, particularly in the context of cell stratification. DSC3/Desmocollin-3 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived DSC3/Desmocollin-3 protein, expressed by E. coli Cell-free, with N-10*His labeled tag.
- Species: Mouse
- Source: E. coli Cell-free
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
DSC3 is a component of intercellular desmosome junctions and plays a key role in orchestrating complex interactions between plaque proteins and intermediate filaments, thereby promoting strong cell-to-cell adhesion. In addition to its adhesive function, DSC3 emerges as a potential contributor to epidermal cell localization, particularly in the context of cell stratification. DSC3/Desmocollin-3 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived DSC3/Desmocollin-3 protein, expressed by E. coli Cell-free, with N-10*His labeled tag.
Background
Desmocollin-3 (DSC3) is a vital component of intercellular desmosome junctions, essential for mediating cell-cell adhesion. Operating within these junctions, DSC3 facilitates the interaction between plaque proteins and intermediate filaments, playing a crucial role in the structural integrity and stability of tissues. Notably, DSC3 may contribute to the positioning and stratification of epidermal cells by mediating differential adhesiveness between cells expressing different isoforms. This suggests its involvement in the regulation of cell arrangements within the epidermal layer. The multifaceted functions of DSC3 underscore its significance in cellular adhesion processes and tissue organization, emphasizing its role in maintaining the proper structure and function of various tissues. (
Technical Parameters
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Species Mouse
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Source E. coli Cell-free
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Tag N-10*His
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Accession
P55850 (R136-R896)
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Gene ID13507
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Molecular Construction
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N-term
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10*His
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DSC3 (R136-R896)
Accession # P55850 -
C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
DSC3; DSC; Prev. DSC4; Desmocollin-3; CDHF3; Desmocollin-4; DSC1; HT-CP; DSC2; Desmocollin 3; Cadherin Family Member 3
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AA Sequence
RWAPIPCSMQENSLGPFPLFLQQVQSDAAQNYTVFYSISGRGADQEPLNWFFIERDTGNLYCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIKIEDENDNYPLFTEAIYAFEVPEGSRLGTVVGTVCATDKDEPDTMHTRLKYSILEQTPPSPGLFSVHPDTGVITTVSHYMDREVVDKYKLIMKVQDMNGQFFGLISTSTCIITVQDSNDNAPTFRQNTYETAVEENTYNVEILRIPVDDKDMINTANWKANFTILKGNENGWFKITTDPVTNEGVLCVVKPLDYEENRQVTLEIGVNNEAPFIKDVANRIPTMNRAMVTVHVKDQNEGPECKPPEQYVRIKENSAVGSKINGYKAYDPETKNSNGLRYKKLQDPKDWVSIEEVSGLLTISKTLDREIMAPRNDMYNITVMAIDQEGKSCTGTLAVNIEDVNDNAPEIIQDYIVICKPKMGYTDISAVDPDEPIHGPPFQFNLANTSPEVNRIWTLNQVNDTAARLSYQKTADVQIYNVPVTVKDRAGQSATKILRVNLCDCTHPSQCPLRSRSAGITLGKWAILAILLGIALLFSVLLTLVCGVVTARKGKHFPEDLAQQNLIISNTEAPGDDRVCSANGFTTHTANNSSQGFCGTMGSGMRNGGQETIEMMKGHQTLDSCRVAGHHHTLDSGRGGHMDTDNCRYTYSEWHSFTQPRLGEKLHVCNQNEDHIPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEEGLDFLNNLEPKFLTLAETCTKR
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Predicted Molecular Mass
86.3 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add 5-50% of glycerol (final concentration). Our default final concentration of glycerol is 50%. Customers could use it as reference.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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