DTX3 Protein, Human
The DTX3 protein is a multifunctional regulator of Notch signaling that regulates intercellular communication and cell fate decisions. Its effects are context-dependent, exhibiting positive and negative regulation depending on the developmental and cellular environment. DTX3 Protein, Human is the recombinant human-derived DTX3 protein, expressed by E. coli , with tag free.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The DTX3 protein is a multifunctional regulator of Notch signaling that regulates intercellular communication and cell fate decisions. Its effects are context-dependent, exhibiting positive and negative regulation depending on the developmental and cellular environment. DTX3 Protein, Human is the recombinant human-derived DTX3 protein, expressed by E. coli , with tag free.
Background
DTX3 emerges as a versatile regulator within the intricate landscape of Notch signaling, a pivotal pathway orchestrating cell-cell communications and governing diverse cell-fate determinations. Its role appears context-dependent, exerting both positive and negative modulation on Notch signaling, contingent upon the specific developmental and cellular milieu. The functional versatility of DTX3 extends to its capacity as an ubiquitin ligase protein in vitro, suggesting its potential involvement in ubiquitin-mediated regulatory mechanisms within the Notch pathway. This dual functionality underscores the complexity and adaptability of DTX3 in fine-tuning Notch signaling dynamics, contributing to the intricate regulatory network governing cellular fate decisions.
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
Q8N9I9 (S2-D347)
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Gene ID196403
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Molecular Construction
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N-term
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DTX3 (S2-D347)
Accession # Q8N9I9 -
C-term
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Protein Length
Full Length
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Synonyms
DTX3; Deltex3; Deltex E3 Ubiquitin Ligase 3; Putative E3 Ubiquitin-Protein Ligase DTX3; RNF154; Probable E3 Ubiquitin-Protein Ligase DTX3; RING-Type E3 Ubiquitin Transferase DTX3; Deltex 3 Homolog (Drosophila); E3 Ubiquitin-Protein Ligase DTX3; Deltex Hom
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AA Sequence
SFVLSRMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDIYVLQLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEMHRAGPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQNAKTLEKCRHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGTIVIQYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTSMTTGRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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