Endoglycan/PODXL2 Protein, Mouse (HEK293, His)

Endoglycan/PODXL2 Protein serves as a ligand for vascular selectins, enabling leukocyte rolling on vascular surfaces via high affinity interactions with E-, P-, and L-selectins. It exists as a disulfide-linked homodimer. Furthermore, Endoglycan/PODXL2 Protein interacts with SELL, SELE, and SELP, enhancing its role in leukocyte adhesion and trafficking in the vasculature. Endoglycan/PODXL2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Endoglycan/PODXL2 protein, expressed by HEK293 , with C-His labeled tag.

Endoglycan/PODXL2 Protein acts as a ligand for vascular selectins, facilitating the rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P-, and L-selectins. It exists as a homodimer linked by disulfide bonds. Additionally, Endoglycan/PODXL2 Protein interacts with SELL (E-selectin), SELE (P-selectin), and SELP (L-selectin), further contributing to its role in mediating leukocyte adhesion and trafficking in the vasculature.

Mouse

HEK293

C-8*His

Q8CAE9-1 (V29-T499)

319655  [NCBI]

Extracellular Domain

VGVDEPGPEGLTSTSLLDLLLPTDFEPLDSEEPSEAMGLDAGLAPGSGFPSEDSEESRLLQPPQYFWEEEELNGSSLDLGPTADYVFPDLTEKVASMEDPGQAPDLPNLPSILPKMDLAEPPWHMPLQEEEEEEEEEEEEREEEEREKEAEEEEEEEELLPVSGSPGATAQAHAPSPSTSSSTSSQSPGATRHRQEDSGDQATSGMEVESSVKPTLSVPSVTPSTVAPGVQNYSQESGGTEWPTGGLGVQSEVPQGAGEGATVGAADFDGQQGALPSSSLPQTVPPSGTEVPSEGPLYPRIPDSLPPGPQDTESTPSSATWGQEGLSEQPLEGQAAEAHSLTPWDSTQVICKDWSNLAGKSYIILNMTQNIDCEVFRRHRGLRLLALVEEVLPRHRSGHRGDWHISLSKPSEKEQHLLMTLVGEQGVVPTQDVLSMLSGIRRSLEEIGIQNYSTTSSCQARATQVRSDYGT

Approximately 80-110 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

≥ 95%, as determined by Bis-Tris PAGE.

<1 EU/μg, determined by LAL method.