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  4. Endoglycan/PODXL2 Protein, Mouse (HEK293, His)

Endoglycan/PODXL2 Protein, Mouse (HEK293, His)

Cat. No.: HY-P78021
Handling Instructions

Endoglycan/PODXL2 Protein serves as a ligand for vascular selectins, enabling leukocyte rolling on vascular surfaces via high affinity interactions with E-, P-, and L-selectins. It exists as a disulfide-linked homodimer. Furthermore, Endoglycan/PODXL2 Protein interacts with SELL, SELE, and SELP, enhancing its role in leukocyte adhesion and trafficking in the vasculature. Endoglycan/PODXL2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Endoglycan/PODXL2 protein, expressed by HEK293, with C-His labeled tag. The total length of Endoglycan/PODXL2 Protein, Mouse (HEK293, His) is 471 a.a., with molecular weight of 80-110 kDa.

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Description

Endoglycan/PODXL2 Protein serves as a ligand for vascular selectins, enabling leukocyte rolling on vascular surfaces via high affinity interactions with E-, P-, and L-selectins. It exists as a disulfide-linked homodimer. Furthermore, Endoglycan/PODXL2 Protein interacts with SELL, SELE, and SELP, enhancing its role in leukocyte adhesion and trafficking in the vasculature. Endoglycan/PODXL2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Endoglycan/PODXL2 protein, expressed by HEK293, with C-His labeled tag. The total length of Endoglycan/PODXL2 Protein, Mouse (HEK293, His) is 471 a.a., with molecular weight of 80-110 kDa.
Background

Endoglycan/PODXL2 Protein acts as a ligand for vascular selectins, facilitating the rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P-, and L-selectins. It exists as a homodimer linked by disulfide bonds. Additionally, Endoglycan/PODXL2 Protein interacts with SELL (E-selectin), SELE (P-selectin), and SELP (L-selectin), further contributing to its role in mediating leukocyte adhesion and trafficking in the vasculature.
Species

Mouse
Source

HEK293
Tag

C-His
Accession

Q8CAE9 (V29-T499)
Gene ID

319655  [NCBI]
Molecular Construction
N-term
Endoglycan (V29-T499)
Accession # Q8CAE9
His
C-term
Synonyms
Endoglycan; PODLX2; brain-1; BRN1; EG; oct-8; OTF8; UNQ1861/PRO3742
Molecular Weight

80-110 kDa
Purity

Greater than 95% as determined by Tris-Bis PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

Endoglycan/PODXL2 Protein, Mouse (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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