Endoglycan/PODXL2 Protein, Mouse (HEK293, His)
Endoglycan/PODXL2 Protein serves as a ligand for vascular selectins, enabling leukocyte rolling on vascular surfaces via high affinity interactions with E-, P-, and L-selectins. It exists as a disulfide-linked homodimer. Furthermore, Endoglycan/PODXL2 Protein interacts with SELL, SELE, and SELP, enhancing its role in leukocyte adhesion and trafficking in the vasculature. Endoglycan/PODXL2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Endoglycan/PODXL2 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
Endoglycan/PODXL2 Protein serves as a ligand for vascular selectins, enabling leukocyte rolling on vascular surfaces via high affinity interactions with E-, P-, and L-selectins. It exists as a disulfide-linked homodimer. Furthermore, Endoglycan/PODXL2 Protein interacts with SELL, SELE, and SELP, enhancing its role in leukocyte adhesion and trafficking in the vasculature. Endoglycan/PODXL2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Endoglycan/PODXL2 protein, expressed by HEK293 , with C-His labeled tag.
Background
Endoglycan/PODXL2 Protein acts as a ligand for vascular selectins, facilitating the rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P-, and L-selectins. It exists as a homodimer linked by disulfide bonds. Additionally, Endoglycan/PODXL2 Protein interacts with SELL (E-selectin), SELE (P-selectin), and SELP (L-selectin), further contributing to its role in mediating leukocyte adhesion and trafficking in the vasculature.
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-8*His
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Accession
Q8CAE9-1 (V29-T499)
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Molecular Construction
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N-term
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Endoglycan (V29-T499)
Accession # Q8CAE9-1 -
8*His
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C-term
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Protein Length
Extracellular Domain
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Synonyms
PODXL2; EG; Podocalyxin Like 2; Podocalyxin-Like Protein 2; Endoglycan; Podocalyxin-Like 2; PODLX2
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AA Sequence
VGVDEPGPEGLTSTSLLDLLLPTDFEPLDSEEPSEAMGLDAGLAPGSGFPSEDSEESRLLQPPQYFWEEEELNGSSLDLGPTADYVFPDLTEKVASMEDPGQAPDLPNLPSILPKMDLAEPPWHMPLQEEEEEEEEEEEEREEEEREKEAEEEEEEEELLPVSGSPGATAQAHAPSPSTSSSTSSQSPGATRHRQEDSGDQATSGMEVESSVKPTLSVPSVTPSTVAPGVQNYSQESGGTEWPTGGLGVQSEVPQGAGEGATVGAADFDGQQGALPSSSLPQTVPPSGTEVPSEGPLYPRIPDSLPPGPQDTESTPSSATWGQEGLSEQPLEGQAAEAHSLTPWDSTQVICKDWSNLAGKSYIILNMTQNIDCEVFRRHRGLRLLALVEEVLPRHRSGHRGDWHISLSKPSEKEQHLLMTLVGEQGVVPTQDVLSMLSGIRRSLEEIGIQNYSTTSSCQARATQVRSDYGT
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Predicted Molecular Mass
51.7 kDa
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Molecular Weight
Approximately 80-110 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by Bis-Tris PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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