EphB1 Protein, Rhesus Macaque (HEK293, His)

EphB1, a tyrosine kinase receptor, was promiscuously bound to the transmembrane ligand ephrin-B family on adjacent cells, initiating contact-dependent bidirectional signaling. The downstream signaling pathway originating from the receptor is called the forward signaling pathway, while the downstream signaling pathway for ephrin ligands is called the reverse signaling pathway. The homologous/functional ligands of this receptor include EFNB1, EFNB2 and EFNB3. In nervous system development, EphB1 regulates retinal axon guidance by redirecting the axons of ventral temporal retinal ganglion cells on the ipsilateral midline of the optic crossover, possibly through repulsive interactions with EFNB2. In the adult nervous system, EphB1, together with EFNB3, controls the chemotaxis, proliferation, and polarity of hippocampal neural progenitors. In addition to axonal guidance, EphB1 also plays a crucial redundant role with other ephrin-B receptors in the development and maturation of dendritic spines and the formation of synapses. EphB1 may regulate angiogenesis and play a role in targeting cell migration and adhesion. After being activated by EFNB1 and other possible ephrin-B ligands, EphB1 activated the MAPK/ERK and JNK signaling cascades, regulating cell migration and adhesion, respectively. EphB1 is involved in maintaining the pool of satellite cells (muscle stem cells) by promoting self-renewal of satellite cells (muscle stem cells) and reducing their activation and differentiation. EphB1 promotes differentiation and maturation of dendritic cells in non-small cell lung cancer^[1][2][3][4].