1. Recombinant Proteins
  2. CD Antigens
  3. FPRP/PTGFRN Protein, Mouse (HEK293, His)

FPRP/PTGFRN Protein, Mouse (HEK293, His)

Cat. No.: HY-P77890
Handling Instructions

The FPRP/PTGFRN Protein inhibits PGF2-alpha binding to its FP receptor, mainly by reducing receptor numbers. It interacts with CD9 and CD81, preventing myotube fusion in myoblasts during muscle regeneration. It also forms a complex with CD9, CD81, and IGSF8, potentially interacting with other tetraspanins like CD63, CD82, and CD151. These interactions highlight its regulatory role in prostaglandin signaling and muscle regeneration. FPRP/PTGFRN Protein, Mouse (HEK293, His) is the recombinant mouse-derived FPRP/PTGFRN protein, expressed by HEK293 , with C-His labeled tag. The total length of FPRP/PTGFRN Protein, Mouse (HEK293, His) is 811 a.a., with molecular weight of 110-120 kDa.

For research use only. We do not sell to patients.

Protein Expression Service

Size Stock
50 μg   Get quote  
100 μg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

The FPRP/PTGFRN Protein inhibits PGF2-alpha binding to its FP receptor, mainly by reducing receptor numbers. It interacts with CD9 and CD81, preventing myotube fusion in myoblasts during muscle regeneration. It also forms a complex with CD9, CD81, and IGSF8, potentially interacting with other tetraspanins like CD63, CD82, and CD151. These interactions highlight its regulatory role in prostaglandin signaling and muscle regeneration. FPRP/PTGFRN Protein, Mouse (HEK293, His) is the recombinant mouse-derived FPRP/PTGFRN protein, expressed by HEK293 , with C-His labeled tag. The total length of FPRP/PTGFRN Protein, Mouse (HEK293, His) is 811 a.a., with molecular weight of 110-120 kDa.

Background

The FPRP/PTGFRN Protein functions as an inhibitor by disrupting the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, primarily by reducing the receptor number rather than affecting the affinity constant. Evidence suggests functional coupling with the PGF2-alpha receptor. In myoblasts, this protein forms associations with tetraspanins CD9 and CD81, effectively preventing myotube fusion during muscle regeneration. Additionally, FPRP/PTGFRN participates in a complex that includes CD9, CD81, and IGSF8. Furthermore, it is likely to interact with other tetraspanins such as CD63, CD82, and CD151. These interactions underscore its regulatory role in cellular processes related to prostaglandin signaling and muscle regeneration.

Species

Mouse

Source

HEK293

Tag

C-His

Accession

Q9WV91 (R22-P832)

Gene ID

19221  [NCBI]

Molecular Construction
N-term
FPRP (R22-P832)
Accession # Q9WV91
His
C-term
Synonyms
Prostaglandin F2 receptor negative regulator; CD9 partner 1; CD9P-1; Glu-Trp-Ile EWI motif-containing protein F; EWI-F; Prostaglandin F2-alpha receptor regulatory protein; Prostaglandin F2-alpha receptor-associated protein; CD_antigen: CD315; CD315
Molecular Weight

110-120 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

FPRP/PTGFRN Protein, Mouse (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
FPRP/PTGFRN Protein, Mouse (HEK293, His)
Cat. No.:
HY-P77890
Quantity:
MCE Japan Authorized Agent: