Fractalkine/CX3CL1 Protein, Human (Biotinylated, HEK293, His)

Fractalkine/CX3CL1 is a chemokine that acts as a ligand to CX3CR1 and the integrins ITGAV: ITGB3 and ITGA4: ITGB1. CX3CL1 promotes lung cancer cell migration and invasion through the Src/FAK signaling pathway. CX3CL1 plays an important role in immune response, inflammation, cell adhesion and chemotaxis. Fractalkine/CX3CL1 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived Fractalkine/CX3CL1 protein, expressed by HEK293 , with C-Avi, C-10*His labeled tag. The total length of Fractalkine/CX3CL1 Protein, Human (Biotinylated, HEK293, His) is 317 a.a., with molecular weight of 50-90 kDa.

Fractalkine/CX3CL1 is a chemokine that acts as a ligand to CX3CR1 and the integrins ITGAV: ITGB3 and ITGA4: ITGB1. CX3CR1-CX3CL1 signaling performs different functions in different tissue comparators, such as immune response, inflammation, cell adhesion, and chemotaxis. CX3CL1 regulates endothelial cell adhesion and migration and activates integrins through CX3Cr1-dependent and CXCr1-independent activation. CX3CL1 promotes lung cancer cell migration and invasion through the Src/FAK signaling pathway^[1][2][3].

Human

HEK293

C-Avi;C-10*His

AAH01163 (Q25-Q341)

6376  [NCBI]

50-90 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized a 0.22 μm filtered solution of 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.