GH/Somatotropin Protein, Human (Biotinylated, HEK293, N-His, C-Avi)
Based on 1 Customer Validation
Growth hormone (GH) plays a key role in growth control, stimulating the release of insulin-like growth factor 1 (IGF-1) from the liver and tissues to promote body growth. It regulates myoblast differentiation and proliferation and contributes significantly to overall organismal development. GH/Somatotropin Protein, Human (Biotinylated, HEK293, N-His, C-Avi) is the recombinant human-derived GH/Somatotropin protein, expressed by HEK293 , with C-Avi, N-10*His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
Growth hormone (GH) plays a key role in growth control, stimulating the release of insulin-like growth factor 1 (IGF-1) from the liver and tissues to promote body growth. It regulates myoblast differentiation and proliferation and contributes significantly to overall organismal development. GH/Somatotropin Protein, Human (Biotinylated, HEK293, N-His, C-Avi) is the recombinant human-derived GH/Somatotropin protein, expressed by HEK293 , with C-Avi, N-10*His labeled tag.
Background
The Somatotropin (GH) protein plays a pivotal role in growth control, exerting its primary influence on body growth by stimulating the liver and other tissues to secrete insulin-like growth factor 1 (IGF-1). GH serves as a potent regulator of both the differentiation and proliferation of myoblasts, contributing significantly to the overall growth and development of the organism. Additionally, it plays a crucial role in enhancing amino acid uptake and promoting protein synthesis in muscle and various tissues. Structurally, GH exists in various forms, including monomers, dimers, trimers, tetramers, and pentamers, either disulfide-linked or non-covalently associated, in homomeric and heteromeric combinations. Furthermore, GH can form complexes with GH binding protein (GHBP) or with the alpha2-macroglobulin complex, underscoring its versatile molecular interactions that contribute to its multifaceted roles in growth regulation and tissue development.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-Avi;N-10*His
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Accession
P01241-1 (F27-F217)
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Molecular Construction
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N-term
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10*His
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GH (F27-F217)
Accession # P01241-1 -
Avi
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C-term
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Protein Length
Full Length of Isoform-1
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Conjugation
Biotin
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Conjugate Method
The single lysine residue in Avitag is biotinylated through an enzymatic reaction.
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Synonyms
GH1; Growth Hormone 1 Variant 2; Growth Hormone 1; Growth Hormone 1 Variant 1; GH-N; Growth Hormone 1 Isoform 1; GH; HCG1749481, Isoform CRA_aa; Pituitary Growth Hormone; Growth Hormone 1 Isoform 2; Somatotropin; HCG1749481, Isoform CRA_s; HGH-N; HCG17494
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AA Sequence
FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISLLLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNYGLLYCFRKDMDKVETFLRIVQCRSVEGSCGF
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Predicted Molecular Mass
26.7 kDa
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Molecular Weight
Approximately 27 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, 6% trehalose, pH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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