glycoprotein C/gC Protein, HHV-2 (Cell-Free, His)
Glycoprotein C (gC protein) is an important attachment protein that promotes virus binding to the cell surface by interacting with heparan sulfate or chondroitin sulfate. This critical role emphasizes its importance during the initial stages of viral infection. glycoprotein C/gC Protein, HHV-2 (Cell-Free, His) is the recombinant Virus-derived glycoprotein C/gC protein, expressed by E. coli Cell-free , with N-10*His labeled tag.
- Species: Virus
- Source: E. coli Cell-free
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
Glycoprotein C (gC protein) is an important attachment protein that promotes virus binding to the cell surface by interacting with heparan sulfate or chondroitin sulfate. This critical role emphasizes its importance during the initial stages of viral infection. glycoprotein C/gC Protein, HHV-2 (Cell-Free, His) is the recombinant Virus-derived glycoprotein C/gC protein, expressed by E. coli Cell-free , with N-10*His labeled tag.
Background
Glycoprotein C (gC Protein) emerges as a crucial attachment protein facilitating virus binding to cell surfaces through interactions with heparan sulfate or chondroitin sulfate. This pivotal role underscores its significance in the initial stages of viral infection. Beyond its attachment function, gC Protein also plays a vital role in immune evasion by inhibiting the activation of the host complement cascade. Its interaction with host complement component C3b leads to the modulation of the complement cascade, disrupting the host immune response. This dual functionality positions gC Protein as a key player in both the viral entry process and the virus's evasion of the host immune system.
Technical Parameters
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Species Virus
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Source E. coli Cell-free
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Tag N-10*His
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Accession
Q89730 (S28-R480)
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Gene ID1487331
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Molecular Construction
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N-term
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10*His
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HHV-2 gC (S28-R480)
Accession # Q89730 -
C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
GC; GcMAF; GC Vitamin D Binding Protein; HDBP; DBP; VDB; Vitamin D-Binding Protein; Epididymis Secretory Protein Li 51; Gc-Globulin; Vitamin D-Binding Alpha-Globulin; VDBP; GC, Vitamin D Binding Protein; Vitamin D-Binding Protein-Macrophage Activating Fac
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AA Sequence
SPGRTITVGPRGNASNAAPSASPRNASAPRTTPTPPQPRKATKSKASTAKPAPPPKTGPPKTSSEPVRCNRHDPLARYGSRVQIRCRFPNSTRTEFRLQIWRYATATDAEIGTAPSLEEVMVNVSAPPGGQLVYDSAPNRTDPHVIWAEGAGPGASPRLYSVVGPLGRQRLIIEELTLETQGMYYWVWGRTDRPSAYGTWVRVRVFRPPSLTIHPHAVLEGQPFKATCTAATYYPGNRAEFVWFEDGRRVFDPAQIHTQTQENPDGFSTVSTVTSAAVGGQGPPRTFTCQLTWHRDSVSFSRRNASGTASVLPRPTITMEFTGDHAVCTAGCVPEGVTFAWFLGDDSSPAEKVAVASQTSCGRPGTATIRSTLPVSYEQTEYICRLAGYPDGIPVLEHHGSHQPPPRDPTERQVIRAVEGAGIGVAVLVAVVLAGTAVVYLTHASSVRYRRLR
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Predicted Molecular Mass
50.5 kDa
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Purity
≥ 85%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add 5-50% of glycerol (final concentration). Our default final concentration of glycerol is 50%. Customers could use it as reference.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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