Glypican-2/GPC2 Protein, Mouse (HEK293, His)
Glypican-2 (GPC2) is a heparan sulfate-containing cell surface proteoglycan that may influence the motor behavior of developing neurons. Glypican-2/GPC2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Glypican-2/GPC2 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
Glypican-2 (GPC2) is a heparan sulfate-containing cell surface proteoglycan that may influence the motor behavior of developing neurons. Glypican-2/GPC2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Glypican-2/GPC2 protein, expressed by HEK293 , with C-His labeled tag.
Background
Glypican-2 (GPC2) Protein is a cell surface proteoglycan characterized by the presence of heparan sulfate. It may play a role in the motile behaviors of developing neurons. GPC2 interacts with Pleiotrophin (PTN) through its heparan sulfate side chains, promoting neurite outgrowth. This interaction involves the binding of PTN with chondroitin sulfate of proteoglycans, leading to the release of protein tyrosine phosphatase receptor sigma (PTPRS) from chondroitin sulfate proteoglycans (CSPGs) and subsequent binding with heparan sulfate of GPC2. Furthermore, GPC2 interacts with Midkine (MDK) through its heparan sulfate chain, inducing GPC2 clustering. This interaction is inhibited by heparin followed by chondroitin sulfate E and induces neuronal cell adhesion and neurite outgrowth.
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-8*His
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Accession
Q8BKV1 (H22-S556)
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Molecular Construction
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N-term
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GPC2 (H22-S556)
Accession # Q8BKV1 -
8*His
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C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
GPC2; Glypican-2; Glypican 2; FLJ38962; Glypican Proteoglycan 2, Cerebroglycan Proteoglycan; Glypican 2 (Cerebroglycan); Cerebroglycan; Cerebroglycan Proteoglycan; DKFZp547M109
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AA Sequence
HGSEAKVVRSCAETRQVLGARGYSLNLIPPSLISGEHLQVCPQEYTCCSSETEQKLIRDAEVTFRGLVEDSGSFLIHTLAARHRKFNEFFREMLSISQHSLAQLFSHSYGRLYSQHAVIFNSLFSGLRDYYEKSGEGLDDTLADFWAQLLERAFPLLHPQYSFPPDFLLCLTRLTSTADGSLQPFGDSPRRLRLQISRALVAARALVQGLETGRNVVSEALKVPVLEGCRQALMRLIGCPLCRGVPSLMPCRGFCLNVAHGCLSSRGLEPEWGGYLDGLLLLAEKLQGPFSFELAAESIGVKISEGLMHLQENSVKVSAKVFQECGTPHPVQSRSRRAPAPREEASRSWRASAEEERPTTAAGTNLHRLVWELRERLSRVRGFWAGLPVTVCGDSRMAADLSQETAPCWTGVGRGRYMSPVVVGSLNEQLHNPELDTSSPDVPTRRRRLHLRAATARMKAAALGQDLDMHDADEDASGSGGGQQYADDWKAGAVPVVPPARPPRPPRPPRRDGLGVRGGSGSARYNQGRSRNLGS
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Predicted Molecular Mass
59.9 kDa
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Molecular Weight
Approximately 25-30 kDa & 30-35 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by Bis-Tris PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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