Glypican-2/GPC2 Protein, Mouse (HEK293, His)

Glypican-2 (GPC2) is a heparan sulfate-containing cell surface proteoglycan that may influence the motor behavior of developing neurons. Glypican-2/GPC2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Glypican-2/GPC2 protein, expressed by HEK293 , with C-His labeled tag.

Glypican-2 (GPC2) Protein is a cell surface proteoglycan characterized by the presence of heparan sulfate. It may play a role in the motile behaviors of developing neurons. GPC2 interacts with Pleiotrophin (PTN) through its heparan sulfate side chains, promoting neurite outgrowth. This interaction involves the binding of PTN with chondroitin sulfate of proteoglycans, leading to the release of protein tyrosine phosphatase receptor sigma (PTPRS) from chondroitin sulfate proteoglycans (CSPGs) and subsequent binding with heparan sulfate of GPC2. Furthermore, GPC2 interacts with Midkine (MDK) through its heparan sulfate chain, inducing GPC2 clustering. This interaction is inhibited by heparin followed by chondroitin sulfate E and induces neuronal cell adhesion and neurite outgrowth.

Mouse

HEK293

C-8*His

Q8BKV1 (H22-S556)

71951  [NCBI]

Full Length of Glypican-2

HGSEAKVVRSCAETRQVLGARGYSLNLIPPSLISGEHLQVCPQEYTCCSSETEQKLIRDAEVTFRGLVEDSGSFLIHTLAARHRKFNEFFREMLSISQHSLAQLFSHSYGRLYSQHAVIFNSLFSGLRDYYEKSGEGLDDTLADFWAQLLERAFPLLHPQYSFPPDFLLCLTRLTSTADGSLQPFGDSPRRLRLQISRALVAARALVQGLETGRNVVSEALKVPVLEGCRQALMRLIGCPLCRGVPSLMPCRGFCLNVAHGCLSSRGLEPEWGGYLDGLLLLAEKLQGPFSFELAAESIGVKISEGLMHLQENSVKVSAKVFQECGTPHPVQSRSRRAPAPREEASRSWRASAEEERPTTAAGTNLHRLVWELRERLSRVRGFWAGLPVTVCGDSRMAADLSQETAPCWTGVGRGRYMSPVVVGSLNEQLHNPELDTSSPDVPTRRRRLHLRAATARMKAAALGQDLDMHDADEDASGSGGGQQYADDWKAGAVPVVPPARPPRPPRPPRRDGLGVRGGSGSARYNQGRSRNLGS

Approximately 30-35 kDa,based on SDS-PAGE under reducing conditions.

≥ 95%, as determined by Bis-Tris PAGE.

<1 EU/μg, determined by LAL method.