GPS1 Protein, Human (sf9)
GPS1 Protein, Human (sf9) is the recombinant human-derived GPS1, expressed by sf9 insect cells , with tag Free labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
GPS1 Protein, Human (sf9) is the recombinant human-derived GPS1, expressed by sf9 insect cells , with tag Free labeled tag.
GPS1 is an essential component of the COP9 signalosome complex (CSN), which participates in various cellular and developmental processes. The CSN complex acts as a crucial regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of cullin subunits in SCF-type E3 ligase complexes (e.g., SCF, CSA, or DDB2), thereby reducing their Ubl ligase activity. It is also involved in the phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, and IRF8/ICSBP, likely through its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects their degradation by the Ubl system, respectively. Additionally, GPS1 suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag Tag Free
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Accession
Q13098-4 (M1-M491)
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Gene ID2873
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Protein Length
Full Length of Isoform-4
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Synonyms
GPS1; SGN1; G Protein Pathway Suppressor 1; COP9 Signalosome Subunit 1; COPS1; Signalosome Subunit 1; CSN1; Protein MFH; JAB1-Containing Signalosome Subunit 1; GPS-1; COP9 Signalosome Complex Subunit 1
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AA Sequence
MPLPVQVFNLQGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRSSLRELQNAPDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKSPPREGSQGELTPANSQSRMSTNM
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Predicted Molecular Mass
55.7 kDa
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Purity
≥ 85%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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