GRM5 Protein, Human (sf9, His)

The GRM5 Protein functions as a G-protein coupled receptor for glutamate, undergoing a conformational change upon ligand binding that initiates signaling through guanine nucleotide-binding proteins (G proteins), ultimately modulating downstream effectors. This signaling cascade activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Integral to the regulation of synaptic plasticity and modulation of neural network activity, GRM5 plays a crucial role in shaping the dynamic responses of the central nervous system. The interaction of the PPXXF motif with HOMER1, HOMER2, and HOMER3 highlights its involvement in intracellular signaling events. Additionally, GRM5 interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3, TAMALIN, and NCDN, with isoform 2 specifically interacting with NECAB2. Further interaction occurs with CAMK2A, emphasizing the intricate network through which GRM5 contributes to the regulation of neural function.