HLA-G Complex Tetramer Protein, Rhesus Macaque (HEK293, His-Avi)

The HLA-G, part of the MHC class I family, is pivotal in immune regulation by presenting antigens to cytotoxic T cells and natural killer cells. Distinct from other MHC class I molecules, it shows limited polymorphism and tissue-specific expression, including in immune-privileged sites and the placenta. Linked to immune tolerance, its expression guards against excessive immune responses. Investigating HLA-G mechanisms offers insights into immune-related disorders and potential therapeutic strategies for immune response modulation. HLA-G Complex Tetramer Protein, Rhesus Macaque (HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-G and B2M/Beta-2 microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and RIIPRHLQL peptide. HLA-G Complex Tetramer Protein, Rhesus Macaque (HEK293, His-Avi), has molecular weight of 260-265 kDa.

The HLA-G belongs to the MHC class I family. It is a crucial component of the immune system and plays a significant role in immune regulation. This protein is involved in presenting antigens to cytotoxic T cells and natural killer cells, thereby influencing immune responses. The HLA-G is unique compared to other MHC class I molecules as it exhibits limited polymorphism and expression in certain tissues, including the placenta and immune-privileged sites. Its expression is associated with immune tolerance and protection against excessive immune responses. Understanding the mechanisms of HLA-G function can provide insights into immune-related disorders and potentially lead to the development of therapeutic strategies for modulation of immune responses.

Rhesus Macaque

HEK293

C-Avi;C-His

O02948 (G25-T305)&Q6V7J5 (I21-M119)&RIIPRHLQL

100187576  [NCBI]&712428  [NCBI]

260-265 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.