HRH3-VLPs Protein, Human (HEK293, GFP)

HRH3-VLPs Protein, Human (HEK293, GFP) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

The HRH3-VLPs protein belongs to the H3 subclass of histamine receptors, playing a potential role in mediating histamine signals within the central nervous system (CNS) and peripheral nervous system. It operates by inhibiting adenylate cyclase and exhibits notable constitutive activity, demonstrating spontaneous activity even in the absence of agonists. Interestingly, stimulation of isoform 3 fails to alter adenylate cyclase activity or induce intracellular calcium mobilization.

Human

HEK293

C-GFP

Q9Y5N1 (M1-K445)

11255

Full Length

MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK

Purity analysis by SDS-PAGE is not available for VLP proteins.

<1 EU/μg, determined by LAL method.