IFNAR1 Protein, Cynomolgus (Biotinylated, HEK293, His, Avi)

IFNAR1 Protein, Cynomolgus (Biotinylated, HEK293, His, Avi) is the recombinant cynomolgus-derived IFNAR1 protein, expressed by HEK293, with C-Avi & C-His tag.

IFNAR1, together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega, and kappa). Binding of type I interferons activates the JAK-STAT signaling cascade. IFNAR1 can also function independently of IFNAR2 by forming an active IFNB1 receptor on its own and initiating a signaling cascade that does not involve the JAK-STAT pathway.

Loaded Biotinylated Cynomolgus IFN alpha / beta R1, His-Avi Tag on Streptavidin-Biosensor, can bind Human IFN alpha 1, hFc Tag with an affinity constant of 1.0-5.0 nM as determined in BLI assay (Gator).

Cynomolgus

HEK293

C-Avi;C-8*His

A0A7N9D7J0 (A25-K437)

101926190

Partial

Biotin

AGGKNLKSPQKVEVDVIDDNFILRWNRSEESVGNVTFSFDYQKPEMDNWIKLPGCQNMTSTKCNFSSLKLNIYDEIKLRIRAEKENTSSWCEVDSFTPFRKAQIGPPEVHLEAEDKAIVIYISPPGTEDSVMWALDRSSFTYSLVIWKNSSSVEERIENIYSRHKISKLSPETTYCLKVKAALLTSRKIGVYGPVHCIKTTVENELPPPENIEVIVQNQNYVLKWDYTYANMTFQVQWLHAFLKRKPGNHLYKWKQIPDCENVTTTQCVFPPNTFQKGIYLLRVQASDGNNTSFWSEEIKFDTEIQASLLPPVFNIRSLSDSLHISIGAPKWSENKPVIQDYPLIYEILFWENTSKAERKIIKKKTDVTIPNLKPLTVYCVKARAHSMDEKLNKSSVFSDVVCEETKSGNTSK

Approximately 75-105 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

≥ 95%, as determined by Bis-Tris PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.