IGF2R Protein, Human (HEK293, His-Avi)

IGF2R Protein orchestrates cellular processes by transporting phosphorylated lysosomal enzymes from the Golgi complex to lysosomes. Lysosomal enzymes, with phosphomannosyl residues, bind to mannose-6-phosphate receptors in the Golgi, forming a complex transported to an acidic prelysosomal compartment. The low pH facilitates complex dissociation, and the receptor is recycled via interaction with the retromer. IGF2R also binds IGF2, positively regulates T-cell coactivation with DPP4, and engages with HA-I and HA-II plasma membrane adapters, showcasing its versatile molecular interactions in intracellular transport. IGF2R Protein, Human (HEK293, His-Avi) is the recombinant human-derived IGF2R protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of IGF2R Protein, Human (HEK293, His-Avi) is 1462 a.a., with molecular weight of 165-200 kDa.

IGF2R Protein serves as a crucial mediator in cellular processes, orchestrating the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes carrying phosphomannosyl residues specifically bind to mannose-6-phosphate receptors in the Golgi apparatus, forming a receptor-ligand complex that is transported to an acidic prelysosomal compartment. The low pH in this compartment facilitates the dissociation of the complex, after which the receptor is recycled back to the Golgi for further trafficking through its interaction with the retromer. Additionally, IGF2R binds IGF2 and acts as a positive regulator of T-cell coactivation by directly interacting with DPP4. The protein further engages with HA-I and HA-II plasma membrane adapters, demonstrating its versatile molecular interactions. Its binding to the heterotrimeric retromer cargo-selective complex highlights its involvement in retrograde trafficking from endosomes to the Golgi apparatus, underscoring its essential role in intracellular transport and cellular homeostasis.

Human

HEK293

C-Avi;C-His

P11717 (E47-M1508)

3482  [NCBI]

165-200 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.