1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. IGF family
  4. IGFBP-2
  5. IGFBP-2 Protein, Mouse (HEK293, Fc)

IGFBP-2 Protein, Mouse (HEK293, Fc)

Cat. No.: HY-P74847
Handling Instructions

IGFBP-2 protein, a member of the IGF-binding protein family, inhibits IGF-mediated growth and developmental rates. It can extend the half-life of IGF and exhibit dual functions by inhibiting or stimulating the growth-promoting effect of IGF in cell culture. IGFBP-2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IGFBP-2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of IGFBP-2 Protein, Mouse (HEK293, Fc) is 305 a.a., with molecular weight of ~56.6 kDa.

For research use only. We do not sell to patients.

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Description

IGFBP-2 protein, a member of the IGF-binding protein family, inhibits IGF-mediated growth and developmental rates. It can extend the half-life of IGF and exhibit dual functions by inhibiting or stimulating the growth-promoting effect of IGF in cell culture. IGFBP-2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IGFBP-2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of IGFBP-2 Protein, Mouse (HEK293, Fc) is 305 a.a., with molecular weight of ~56.6 kDa.

Background

IGFBP-2 protein acts as an inhibitor, specifically targeting IGF-mediated growth and developmental rates. As a member of the IGF-binding protein family, IGFBP-2 prolongs the half-life of IGFs and exhibits dual functionality, either inhibiting or stimulating the growth-promoting effects of IGFs in cell culture. This modulation occurs through the alteration of the interaction between IGFs and their cell surface receptors. Notably, IGFBP-2 demonstrates a higher binding affinity for IGF2 compared to IGF1, underscoring its role in finely regulating the intricate balance of IGF signaling pathways.

Species

Mouse

Source

HEK293

Tag

C-hFc

Accession

P47877 (M1-Q305)

Gene ID

16008  [NCBI]

Molecular Construction
N-term
IGFBP-2 (M1-Q305)
Accession # P47877
hFc
C-term
Synonyms
IBP-2; Insulin-like growth factor binding protein 2; IGFBP2; IGF-BP53
Molecular Weight

Approximately 56.6 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

IGFBP-2 Protein, Mouse (HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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IGFBP-2 Protein, Mouse (HEK293, Fc)
Cat. No.:
HY-P74847
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