IGFBP-4 Protein, Human (Biotinylated, HEK293, His-Avi)
IGFBP-4 protein is an important IGFBP member that prolongs the half-life of insulin-like growth factor (IGF) and modulates its effects on cell cultures by altering the kinetics of interaction with cell surface receptors. It can inhibit or stimulate IGF-induced growth responses, showing specificity for IGF2 but not IGF1. IGFBP-4, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IGFBP-4 protein, expressed by HEK293, with C-Avi;C-His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
IGFBP-4 protein is an important IGFBP member that prolongs the half-life of insulin-like growth factor (IGF) and modulates its effects on cell cultures by altering the kinetics of interaction with cell surface receptors. It can inhibit or stimulate IGF-induced growth responses, showing specificity for IGF2 but not IGF1. IGFBP-4, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IGFBP-4 protein, expressed by HEK293, with C-Avi;C-His labeled tag.
Background
IGFBP-4 Protein, a member of the insulin-like growth factor-binding proteins (IGFBPs), plays a vital role in extending the half-life of insulin-like growth factors (IGFs) and modulating their effects on cell culture. With the ability to either inhibit or stimulate IGF-induced growth-promoting effects, IGFBP-4 achieves this regulatory function by altering the interaction dynamics between IGFs and their respective cell surface receptors. Notably, IGFBP-4 exhibits a preferential binding affinity for IGF2 over IGF1, highlighting its specificity in modulating the interactions between different IGF isoforms and their receptors. This differential binding capacity underscores the intricate regulatory role of IGFBP-4 in fine-tuning the cellular responses to IGFs, emphasizing its significance in the complex network that governs growth-related signaling pathways.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-Avi;C-His
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Accession
P22692-1 (D22-E258)
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Gene ID3487
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Molecular Construction
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N-term
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IGFBP-4 (D22-E258)
Accession # P22692-1 -
His-Avi
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C-term
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Protein Length
Full Length of Isoform-1
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Conjugation
Biotin
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Synonyms
IGFBP4; IGF-Binding Protein 4; Insulin Like Growth Factor Binding Protein 4; HT29-IGFBP; IGFBP-4; BP-4; IBP4; IBP-4; Insulin-Like Growth Factor-Binding Protein 4; Insulin-Like Growth Factor Binding Protein 4
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AA Sequence
DEAIHCPPCSEEKLARCRPPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGLRCYPPRGVEKPLHTLMHGQGVCMELAEIEAIQESLQPSDKDEGDHPNNSFSPCSAHDRRCLQKHFAKIRDRSTSGGKMKVNGAPREDARPVPQGSCQSELHRALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSFRE
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Predicted Molecular Mass
29.6 kDa
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Molecular Weight
Approximately 35-40 kDa & 41-42 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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