KBTBD2 Protein, Human (sf9)
KBTBD2 in the BCR E3 ubiquitin ligase complex is a key regulator in the insulin signaling pathway and affects the insulin sensitivity of adipocytes. Its effects are manifested by regulating PIK3R1/p85alpha abundance by coordinating the ubiquitination process for PIK3R1 degradation. KBTBD2 Protein, Human (sf9) is the recombinant human-derived KBTBD2 protein, expressed by sf9 insect cells , with tag free.
- Species: Human
- Source: Sf9 insect cells
-
Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Technical Parameters
-
Product Properties
- Documentation
- Help & FAQs
Biological Activity
KBTBD2 in the BCR E3 ubiquitin ligase complex is a key regulator in the insulin signaling pathway and affects the insulin sensitivity of adipocytes. Its effects are manifested by regulating PIK3R1/p85alpha abundance by coordinating the ubiquitination process for PIK3R1 degradation. KBTBD2 Protein, Human (sf9) is the recombinant human-derived KBTBD2 protein, expressed by sf9 insect cells , with tag free.
KBTBD2, functioning as a substrate-specific adapter within the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex, emerges as a key regulator in the insulin signaling pathway with a pronounced impact on insulin sensitivity in adipocytes. This regulatory role is executed through the modulation of PIK3R1/p85alpha abundance, the regulatory subunit of phosphatidylinositol 3-kinase (PI3K). Notably, KBTBD2 orchestrates the ubiquitination process targeting PIK3R1 for 'Lys-48'-linked polyubiquitination, leading to its subsequent proteasome-mediated degradation. The intricate protein modification mechanism orchestrated by KBTBD2, specifically its role in protein ubiquitination, underscores its pivotal function in fine-tuning the insulin signaling cascade and, by extension, insulin sensitivity within adipocytes.
Technical Parameters
-
Species Human
-
Source Sf9 insect cells
-
Tag Tag Free
-
Accession
Q8IY47 (S2-V623)
-
Gene ID25948
-
Molecular Construction
-
N-term
-
KBTBD2 (S2-V623)
Accession # Q8IY47 -
C-term
-
-
Protein Length
Partial
-
Synonyms
KBTBD2; BTB And Kelch Domain-Containing Protein 1; Prev. BKLHD1; DKFZP566C134; Kelch Repeat And BTB (POZ) Domain Containing 2; KIAA1489; Kelch Repeat And BTB Domain-Containing Protein 2; Kelch Repeat And BTB Domain Containing 2; BTB And Kelch Domain Conta
-
AA Sequence
STQDERQINTEYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPNDKSVVVQGLYKSMPKFFKPRLGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPPADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHDCIYVMTLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSVTVEIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNSLCVFMRETHLNERAKYVTYQYDLELDRWSLRQHISERVLWDLGRDFRCTVGKLYPSCLEESPWKPPTYLFSTDGTEEFELDGEMVALPPV
-
Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz
