KLHL21 Protein, Human (sf9, His, StrepⅡ)

KLHL21, serving as the substrate-specific adapter within the BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, plays a crucial role in ensuring efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex is instrumental in orchestrating the localization dynamics of the chromosomal passenger complex (CPC) during anaphase, facilitating its transition from chromosomes to the spindle midzone. Furthermore, this complex actively mediates the ubiquitination of AURKB, a key player in the regulation of cell division. It is noteworthy that, despite the ubiquitination of AURKB by the BCR(KLHL21) E3 ubiquitin ligase complex, this may not necessarily lead to its degradation by the proteasome, highlighting the nuanced nature of protein modification processes governed by KLHL21. The intricate interplay within the BCR(KLHL21) complex underscores its pivotal role in the regulation of cell division through precise control of CPC localization and AURKB ubiquitination, thus contributing to the orchestration of essential cellular events.