Lymphocyte antigen 86/MD-1 Protein, Mouse (HEK293, His, solution)
Based on 1 Customer Validation
Lymphocyte antigen 86/MD-1 acts synergistically with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and influence cytokine production.It plays a crucial role in promoting the high expression of CD180 on the cell surface, forming an M-shaped tetramer with two CD180-LY86 heterodimers.Lymphocyte antigen 86/MD-1 Protein, Mouse (HEK293, His, solution) is the recombinant mouse-derived Lymphocyte antigen 86/MD-1 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
Lymphocyte antigen 86/MD-1 acts synergistically with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and influence cytokine production.It plays a crucial role in promoting the high expression of CD180 on the cell surface, forming an M-shaped tetramer with two CD180-LY86 heterodimers.Lymphocyte antigen 86/MD-1 Protein, Mouse (HEK293, His, solution) is the recombinant mouse-derived Lymphocyte antigen 86/MD-1 protein, expressed by HEK293 , with C-His labeled tag.
Background
The Lymphocyte antigen 86/MD-1 protein emerges as a potential collaborator with CD180 and TLR4, mediating the innate immune response to bacterial lipopolysaccharide (LPS) and influencing cytokine production. Additionally, Lymphocyte antigen 86/MD-1 plays a crucial role in facilitating efficient CD180 cell surface expression. The structural arrangement involves the formation of an M-shaped tetramer, comprising two CD180-LY86 heterodimers. These characteristics underscore the multifaceted nature of Lymphocyte antigen 86/MD-1 in orchestrating immune responses and cellular interactions. Further exploration is essential to unravel the specific molecular mechanisms through which Lymphocyte antigen 86/MD-1 contributes to the intricate dynamics of the innate immune system and its collaboration with CD180 and TLR4 in response to bacterial LPS.
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-His
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Accession
O88188 (D20-S162)
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Molecular Construction
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N-term
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Ly86 (M1-S162)
Accession # O88188 -
His
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C-term
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Protein Length
Full Length
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Synonyms
LY86; Ly-86; Lymphocyte Antigen 86; MD1; DJ80N2.1; MD-1, RP105-Associated; MD-1; MMD-1; Protein MD-1
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AA Sequence
DHGSENGWPKHTACNSGGLEVVYQSCDPLQDFGLSIDQCSKQIQSNLNIRFGIILRQDIRKLFLDITLMAKGSSILNYSYPLCEEDQPKFSFCGRRKGEQIYYAGPVNNPGLDVPQGEYQLLLELYNENRATVACANATVTSS
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Predicted Molecular Mass
18 kDa
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Molecular Weight
Approximately 24-30 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (236 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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