Lymphocyte antigen 86/MD-1 Protein, Mouse (HEK293, His)

Lymphocyte antigen 86/MD-1 acts synergistically with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and influence cytokine production. It plays a crucial role in promoting the high expression of CD180 on the cell surface, forming an M-shaped tetramer with two CD180-LY86 heterodimers. Lymphocyte antigen 86/MD-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Lymphocyte antigen 86/MD-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Lymphocyte antigen 86/MD-1 Protein, Mouse (HEK293, His) is 162 a.a., with molecular weight of 24-30 kDa.

The Lymphocyte antigen 86/MD-1 protein emerges as a potential collaborator with CD180 and TLR4, mediating the innate immune response to bacterial lipopolysaccharide (LPS) and influencing cytokine production. Additionally, Lymphocyte antigen 86/MD-1 plays a crucial role in facilitating efficient CD180 cell surface expression. The structural arrangement involves the formation of an M-shaped tetramer, comprising two CD180-LY86 heterodimers. These characteristics underscore the multifaceted nature of Lymphocyte antigen 86/MD-1 in orchestrating immune responses and cellular interactions. Further exploration is essential to unravel the specific molecular mechanisms through which Lymphocyte antigen 86/MD-1 contributes to the intricate dynamics of the innate immune system and its collaboration with CD180 and TLR4 in response to bacterial LPS.

Mouse

HEK293

C-His

O88188 (M1-S162)

17084  [NCBI]

24-30 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.