MLK3 Protein, Human (Active, sf9, His-GST)
MLK3 Protein, Human (Active, sf9, GST) is the recombinant human-derived MLK3, expressed by Sf9 insect cells , with N-GST labeled tag. ,
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
MLK3 Protein, Human (Active, sf9, GST) is the recombinant human-derived MLK3, expressed by Sf9 insect cells , with N-GST labeled tag. ,
Background
MLK3 is a kinase that activates the JUN N-terminal pathway. It plays a crucial role in serum-stimulated cell proliferation and mediates the activation of MAPK14 (p38), MAPK3 (ERK), and MAPK8 (JNK1) by mitogens and cytokines through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Additionally, MLK3 is involved in mitogen-stimulated phosphorylation and activation of BRAF, though it does not directly phosphorylate BRAF. It also influences microtubule organization during the cell cycle.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag N-6*His;N-GST
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Accession
Q16584-1 (Y99-G398)
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Gene ID4296
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Molecular Construction
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N-term
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GST
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MLK3 (Y99-G398)
Accession # Q16584-1 -
C-term
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Protein Length
Partial
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Synonyms
MAP3K11; Src-Homology 3 Domain-Containing Proline-Rich Kinase; Prev. MLK3; SH3 Domain-Containing Proline-Rich Kinase; Prev. PTK1; Protein-Tyrosine Kinase PTK1; SPRK; MLK-3; MEKK11; Mitogen-Activated Protein Kinase Kinase Kinase 11; Mixed Lineage Kinase 3
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AA Sequence
YVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEG
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Predicted Molecular Mass
63.4 kDa
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Purity
≥ 85%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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