NGL-1/LRRC4C Protein, Mouse (HEK293, His)
Based on 1 Customer Validation
NGL-1/LRRC4C protein promotes neurite outgrowth in thalamic neurons, shaping neural circuit architecture. It interacts with NTNG1 and WHRN to modulate neurite outgrowth and synaptic connections. Investigating its mechanisms and downstream effects could provide insights into its role in neural development and circuit formation. NGL-1/LRRC4C Protein, Mouse (HEK293, His) is the recombinant mouse-derived NGL-1/LRRC4C protein, expressed by HEK293 , with C-His labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
NGL-1/LRRC4C protein promotes neurite outgrowth in thalamic neurons, shaping neural circuit architecture. It interacts with NTNG1 and WHRN to modulate neurite outgrowth and synaptic connections. Investigating its mechanisms and downstream effects could provide insights into its role in neural development and circuit formation. NGL-1/LRRC4C Protein, Mouse (HEK293, His) is the recombinant mouse-derived NGL-1/LRRC4C protein, expressed by HEK293 , with C-His labeled tag.
Background
The NGL-1/LRRC4C protein appears to play a role in promoting neurite outgrowth in developing thalamic neurons, suggesting its involvement in the intricate processes of neuronal growth and connectivity. Its potential to facilitate the extension of neurites implies a key function in shaping the architecture of neural circuits. Additionally, NGL-1/LRRC4C interacts with NTNG1 and WHRN, indicating its participation in molecular interactions that could further modulate neurite outgrowth and influence the development of synaptic connections. Further exploration into the specific mechanisms and downstream effects of NGL-1/LRRC4C in promoting neurite outgrowth and its interactions with NTNG1 and WHRN could provide valuable insights into its role in neural development and circuit formation.
Verified Bioactivity
Measured by its binding ability in a functional ELISA. Immobilized Mouse NGL-1 at 2 μg/mL (100 μL/well) can bind Human NTNG1(HY-P71176). The KD for this effect is 3.013 nM.
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-10*His
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Accession
Q8C031/BAC27884.1 (Q45-K527)
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Molecular Construction
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N-term
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LRRC4C (Q45-K527)
Accession # Q8C031/BAC27884.1 -
His
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C-term
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Protein Length
Partial
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Synonyms
LRRC4C; Leucine-Rich Repeat-Containing Protein 4C; Leucine Rich Repeat Containing 4C; Netrin-G Ligand-1; NGL-1; Netrin-G1 Ligand; KIAA1580; NGL1
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AA Sequence
QTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIRDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRASTSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTPFSYFSTVTVETMEPSQDEARTTDNNVGPTPVIDWETTNVTTSLTPQSTRSTEKTFTIPVTDINSGIPGIDEVMKTTK
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Molecular Weight
Approximately 95-115 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 5% trehalose, 5% mannitol and 0.01% Tween 80.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (238 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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