NGL-1/LRRC4C Protein, Mouse (HEK293, His)

NGL-1/LRRC4C protein promotes neurite outgrowth in thalamic neurons, shaping neural circuit architecture. It interacts with NTNG1 and WHRN to modulate neurite outgrowth and synaptic connections. Investigating its mechanisms and downstream effects could provide insights into its role in neural development and circuit formation. NGL-1/LRRC4C Protein, Mouse (HEK293, His) is the recombinant mouse-derived NGL-1/LRRC4C protein, expressed by HEK293 , with C-His labeled tag.

The NGL-1/LRRC4C protein appears to play a role in promoting neurite outgrowth in developing thalamic neurons, suggesting its involvement in the intricate processes of neuronal growth and connectivity. Its potential to facilitate the extension of neurites implies a key function in shaping the architecture of neural circuits. Additionally, NGL-1/LRRC4C interacts with NTNG1 and WHRN, indicating its participation in molecular interactions that could further modulate neurite outgrowth and influence the development of synaptic connections. Further exploration into the specific mechanisms and downstream effects of NGL-1/LRRC4C in promoting neurite outgrowth and its interactions with NTNG1 and WHRN could provide valuable insights into its role in neural development and circuit formation.

Measured by its binding ability in a functional ELISA. Immobilized Mouse NGL-1 at 2 μg/mL (100 μL/well) can bind Human NTNG1(HY-P71176). The KD for this effect is 3.013 nM.

Mouse

HEK293

C-10*His

Q8C031/BAC27884.1 (Q45-K527)

241568  [NCBI]

Partial

QTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIRDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRASTSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTPFSYFSTVTVETMEPSQDEARTTDNNVGPTPVIDWETTNVTTSLTPQSTRSTEKTFTIPVTDINSGIPGIDEVMKTTK

Approximately 95-115 kDa due to the glycosylation.

≥ 95%, as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 5% trehalose, 5% mannitol and 0.01% Tween 80.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.