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  4. NLGN4X Protein, Human (635a.a, HEK293, His)

NLGN4X Protein, Human (635a.a, HEK293, His)

Cat. No.: HY-P71165
Handling Instructions

The NLGN4X protein is a cell surface protein involved in cell-cell interactions through neurotoxin family interactions. NLGN4X Protein, Human (635a.a, HEK293, His) is the recombinant human-derived NLGN4X protein, expressed by HEK293 , with C-6*His labeled tag. The total length of NLGN4X Protein, Human (635a.a, HEK293, His) is 635 a.a., with molecular weight of ~95.0 kDa.

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Description

The NLGN4X protein is a cell surface protein involved in cell-cell interactions through neurotoxin family interactions. NLGN4X Protein, Human (635a.a, HEK293, His) is the recombinant human-derived NLGN4X protein, expressed by HEK293 , with C-6*His labeled tag. The total length of NLGN4X Protein, Human (635a.a, HEK293, His) is 635 a.a., with molecular weight of ~95.0 kDa.
Background

NLGN4X Protein, a cell surface protein, actively participates in cell-cell interactions through its engaging interactions with neurexin family members. Existing as a homodimer, NLGN4X engages in a calcium-dependent interaction with NRXN1, and the binding with neurexins is facilitated by heparan sulfate glycan modification on neurexin. Notably, its C-terminus forms an interaction with DLG4/PSD-95 third PDZ domain, emphasizing its role in intricate cellular signaling processes. This multifaceted engagement highlights NLGN4X's significance in mediating molecular interactions that contribute to cellular adhesion and communication.
Species

Human
Source

HEK293
Tag

C-6*His
Accession

Q8N0W4 (Q42-S676)
Gene ID
Molecular Construction
N-term
NLGN4X (Q42-S676)
Accession # Q8N0W4
6*His
C-term
Synonyms
Neuroligin-4 X-Linked; Neuroligin X; HNLX; NLGN4X; KIAA1260; NLGN4
AA Sequence

QAQYPVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNMLDTTDMVECLRNKNYKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNLNEIFQYVSTTTKVPPPDMTSFPYGTRRSPAKIWPTTKRPAITPANNPKHSKDPHKTGPEDTTVLIETKRDYSTELS

Molecular Weight

Approximately 95.0 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

NLGN4X Protein, Human (635a.a, HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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