NLGN4X Protein, Human (HEK293, His)
The NLGN4X protein is a cell surface protein involved in cell-cell interactions through neurotoxin family interactions. NLGN4X Protein, Human (HEK293, His) is the recombinant human-derived NLGN4X protein, expressed by HEK293 , with C-6*His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The NLGN4X protein is a cell surface protein involved in cell-cell interactions through neurotoxin family interactions. NLGN4X Protein, Human (HEK293, His) is the recombinant human-derived NLGN4X protein, expressed by HEK293 , with C-6*His labeled tag.
Background
NLGN4X Protein, a cell surface protein, actively participates in cell-cell interactions through its engaging interactions with neurexin family members. Existing as a homodimer, NLGN4X engages in a calcium-dependent interaction with NRXN1, and the binding with neurexins is facilitated by heparan sulfate glycan modification on neurexin. Notably, its C-terminus forms an interaction with DLG4/PSD-95 third PDZ domain, emphasizing its role in intricate cellular signaling processes. This multifaceted engagement highlights NLGN4X's significance in mediating molecular interactions that contribute to cellular adhesion and communication.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-6*His
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Accession
Q8N0W4-1 (Q42-S676)
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Molecular Construction
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N-term
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NLGN4X (Q42-S676)
Accession # Q8N0W4-1 -
6*His
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C-term
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Protein Length
Extracellular Domain
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Synonyms
NLGN4X; Neuroligin 4; Prev. NLGN4; ASPGX2; KIAA1260; AUTSX2; HLNX; HNL4X; Neuroligin-4, X-Linked; HNLX; NLGN; Neuroligin 4 X-Linked; Neuroligin X
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AA Sequence
QAQYPVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNMLDTTDMVECLRNKNYKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNLNEIFQYVSTTTKVPPPDMTSFPYGTRRSPAKIWPTTKRPAITPANNPKHSKDPHKTGPEDTTVLIETKRDYSTELS
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Predicted Molecular Mass
72.5 kDa
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Molecular Weight
Approximately 95 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US;may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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