NLGN4X Protein, Human (HEK293, His)

The NLGN4X protein is a cell surface protein involved in cell-cell interactions through neurotoxin family interactions. NLGN4X Protein, Human (HEK293, His) is the recombinant human-derived NLGN4X protein, expressed by HEK293 , with C-6*His labeled tag.

NLGN4X Protein, a cell surface protein, actively participates in cell-cell interactions through its engaging interactions with neurexin family members. Existing as a homodimer, NLGN4X engages in a calcium-dependent interaction with NRXN1, and the binding with neurexins is facilitated by heparan sulfate glycan modification on neurexin. Notably, its C-terminus forms an interaction with DLG4/PSD-95 third PDZ domain, emphasizing its role in intricate cellular signaling processes. This multifaceted engagement highlights NLGN4X's significance in mediating molecular interactions that contribute to cellular adhesion and communication.

Human

HEK293

C-6*His

Q8N0W4-1 (Q42-S676)

57502  [NCBI]

Extracellular Domain

QAQYPVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNMLDTTDMVECLRNKNYKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNLNEIFQYVSTTTKVPPPDMTSFPYGTRRSPAKIWPTTKRPAITPANNPKHSKDPHKTGPEDTTVLIETKRDYSTELS

Approximately 95 kDa,based on SDS-PAGE under reducing conditions.

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.