NTAL Protein, Human (HEK293, His)

NTAL protein is critical for FCER1 downstream signaling in mast cells and is involved in BCR-mediated signaling in B cells and FCGR1-mediated signaling in myeloid cells. It acts as a molecular bridge, recruiting GRB2 upon phosphorylation, linking receptor activation to intracellular responses. NTAL Protein, Human (HEK293, His) is the recombinant human-derived NTAL protein, expressed by HEK293 , with C-6*His labeled tag.

NTAL protein plays a crucial role in mediating signaling events downstream of high-affinity immunoglobulin epsilon receptor (FCER1) in mast cells. Additionally, it is implicated in B-cell antigen receptor (BCR)-mediated signaling in B-cells and high-affinity immunoglobulin gamma Fc receptor I (FCGR1)-mediated signaling in myeloid cells. NTAL acts as a molecular bridge, facilitating the connection between receptor activation and subsequent intracellular responses by recruiting GRB2 when phosphorylated. Furthermore, it exhibits potential interactions with key signaling molecules, including SOS1, GAB1, and CBL, underscoring its involvement in orchestrating diverse cellular pathways in response to immunoreceptor activation.

Human

HEK293

C-6*His

Q9GZY6 (R27-A243)

7462  [NCBI]

Cytoplasmic Domain

RCSRPGAKRSEKIYQQRSLREDQQSFTGSRTYSLVGQAWPGPLADMAPTRKDKLLQFYPSLEDPASSRYQNFSKGSRHGSEEAYIDPIAMEYYNWGRFSKPPEDDDANSYENVLICKQKTTETGAQQEGIGGLCRGDLSLSLALKTGPTSGLCPSASPEEDEESEDYQNSASIHQWRESRKVMGQLQREASPGPVGSPDEEDGEPDYVNGEVAATEA

Approximately 35-40 kDa,based on SDS-PAGE under reducing conditions.

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.