NTAL Protein, Human (HEK293, His)
NTAL protein is critical for FCER1 downstream signaling in mast cells and is involved in BCR-mediated signaling in B cells and FCGR1-mediated signaling in myeloid cells. It acts as a molecular bridge, recruiting GRB2 upon phosphorylation, linking receptor activation to intracellular responses. NTAL Protein, Human (HEK293, His) is the recombinant human-derived NTAL protein, expressed by HEK293 , with C-6*His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
NTAL protein is critical for FCER1 downstream signaling in mast cells and is involved in BCR-mediated signaling in B cells and FCGR1-mediated signaling in myeloid cells. It acts as a molecular bridge, recruiting GRB2 upon phosphorylation, linking receptor activation to intracellular responses. NTAL Protein, Human (HEK293, His) is the recombinant human-derived NTAL protein, expressed by HEK293 , with C-6*His labeled tag.
Background
NTAL protein plays a crucial role in mediating signaling events downstream of high-affinity immunoglobulin epsilon receptor (FCER1) in mast cells. Additionally, it is implicated in B-cell antigen receptor (BCR)-mediated signaling in B-cells and high-affinity immunoglobulin gamma Fc receptor I (FCGR1)-mediated signaling in myeloid cells. NTAL acts as a molecular bridge, facilitating the connection between receptor activation and subsequent intracellular responses by recruiting GRB2 when phosphorylated. Furthermore, it exhibits potential interactions with key signaling molecules, including SOS1, GAB1, and CBL, underscoring its involvement in orchestrating diverse cellular pathways in response to immunoreceptor activation.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-6*His
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Accession
Q9GZY6 (R27-A243)
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Molecular Construction
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N-term
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NTAL (R27-A243)
Accession # Q9GZY6 -
6*His
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C-term
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Protein Length
Cytoplasmic Domain
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Synonyms
LAT2; Williams-Beuren Syndrome Chromosomal Region 15 Protein; Prev. WBSCR15; Membrane-Associated Adapter Molecule; Prev. WBSCR5; Linker For Activation Of B-Cells; NTAL; Non-T-Cell Activation Linker; LAB; Linker For Activation Of T Cells Family, Member 2;
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AA Sequence
RCSRPGAKRSEKIYQQRSLREDQQSFTGSRTYSLVGQAWPGPLADMAPTRKDKLLQFYPSLEDPASSRYQNFSKGSRHGSEEAYIDPIAMEYYNWGRFSKPPEDDDANSYENVLICKQKTTETGAQQEGIGGLCRGDLSLSLALKTGPTSGLCPSASPEEDEESEDYQNSASIHQWRESRKVMGQLQREASPGPVGSPDEEDGEPDYVNGEVAATEA
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Predicted Molecular Mass
25 kDa
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Molecular Weight
Approximately 35-40 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US;may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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