PCSK1 Protein, Human (HEK293, His)

The PCSK1 protein is a proprotein convertase that plays a key role in processing hormone and protein precursors at sites with basic amino acid residues. It targets multiple substrates such as POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP. PCSK1 Protein, Human (HEK293, His) is the recombinant human-derived PCSK1 protein, expressed by HEK293 , with C-His labeled tag. The total length of PCSK1 Protein, Human (HEK293, His) is 617 a.a., with molecular weight of ~66 kDa.

The PCSK1 Protein plays a pivotal role in the processing of hormone and other protein precursors, particularly at sites characterized by pairs of basic amino acid residues. Functioning as a proprotein convertase, PCSK1 targets a range of substrates, including POMC, renin, enkephalin, dynorphin, somatostatin, insulin, and AGRP. Through its enzymatic activity, PCSK1 is involved in the proteolytic cleavage and maturation of these precursor molecules, thereby regulating the generation of active hormones and neuropeptides. The diverse substrates highlight the broad impact of PCSK1 on the processing of proteins crucial for various physiological functions, including metabolism, endocrine signaling, and neuropeptide regulation.

Human

HEK293

C-His

P29120 (M1-R617)

5122  [NCBI]

Approximately 66 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.