PDGFRB Protein, Human (Biotinylated, HEK293, His)
Based on 1 Customer Validation
TRF1 protein is a telomere-binding protein that plays a crucial role in telomere maintenance and chromosome stability. It is involved in regulating telomere length and preventing DNA damage. PDGFRB Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived PDGFRB Protein, expressed by HEK293 , with C-His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
TRF1 protein is a telomere-binding protein that plays a crucial role in telomere maintenance and chromosome stability. It is involved in regulating telomere length and preventing DNA damage. PDGFRB Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived PDGFRB Protein, expressed by HEK293 , with C-His labeled tag.
Background
The PDGFRB Protein encodes a cell surface tyrosine kinase receptor that interacts with members of the platelet-derived growth factor family, known mitogens for cells of mesenchymal origin. The identity of the growth factor binding to a receptor monomer determines whether the functional receptor forms a homodimer (with PDGFB or PDGFD) or a heterodimer (with PDGFA and PDGFB). Essential for normal cardiovascular system development and the rearrangement of the actin cytoskeleton, this gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor, with all three potentially implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, resulting in the fusion of this gene with that of the ETV6 gene, leads to chronic myeloproliferative disorder with eosinophilia. Broadly expressed, the PDGF R beta gene exhibits elevated levels in the gall bladder (RPKM 79.5), placenta (RPKM 61.0), and 21 other tissues, indicating its involvement in diverse physiological contexts across multiple organs.
Verified Bioactivity
1.This product does not contain protein kinase domain.
2.Measured by its binding ability in a functional ELISA. Immobilized biotinylated human PDGFRb-His at 10 μg/mL (100 μL/well) can bind Cynomolgus PDGFB-Fc, The EC50 of Cynomolgus PDGFB-Fc is 10-80 ng/mL.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-His
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Accession
NP_002600.1 (L33-K531)
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Molecular Construction
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N-term
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PDGF R beta (L33-K531)
Accession # NP_002600.1 -
His
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C-term
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Protein Length
Partial Extracellular Domain
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Conjugation
Biotin
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Synonyms
PDGFRB; PDGFR-Beta; Prev. PDGFR; Beta Platelet-Derived Growth Factor Receptor; PDGFR1; Activated Tyrosine Kinase PDGFRB; CD140b; CD140b Antigen; JTK12; NDEL1-PDGFRB; Platelet-Derived Growth Factor Receptor, Beta Polypeptide; IBGC4; Beta-Type Platelet-Deri
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AA Sequence
LVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFK
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Predicted Molecular Mass
57.6 kDa
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.2 μm filtered solution of Sterile PBS, pH 7.4.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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