PRTN3 Protein, Human (S203A, HEK293, His)

PRTN3, a serine protease, broadly targets elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV in vitro, playing a crucial role in extracellular matrix degradation. It modulates endothelial cell barrier function by cleaving and activating the receptor F2RL1/PAR-2, enhancing vascular integrity during neutrophil transendothelial migration. Its potential involvement in this process, particularly when associated with CD177, underscores its significance in immune-related functions. PRTN3 Protein, Human (S203A, HEK293, His) is the recombinant human-derived PRTN3 protein, expressed by HEK293 , with C-His labeled tag and I28-P256 mutation. The total length of PRTN3 Protein, Human (S203A, HEK293, His) is 229 a.a., with molecular weight of ~26.57 kDa.

PRTN3, a serine protease, exhibits a broad substrate specificity, targeting elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV in vitro. Its enzymatic activity plays a crucial role in the degradation of these extracellular matrix components. Additionally, PRTN3 takes part in the modulation of endothelial cell barrier function by cleaving and activating the receptor F2RL1/PAR-2, thereby enhancing vascular integrity during neutrophil transendothelial migration. Notably, its potential involvement in neutrophil transendothelial migration is suggested, particularly when associated with CD177, emphasizing its significance in immune-related processes.

Human

HEK293

C-His

P24158 (S203A, I28-P256)

5657  [NCBI]

Approximately 26.57 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.