RAB6A Protein, Human (His)
Based on 1 Customer Validation
RAB6A protein forms a complex with BICD1 and directly interacts with DYNLRB1 in the GDP-bound state, suggesting a regulatory role in coordinating cellular functions. In the GTP-bound state, RAB6A interacts with VPS13B, suggesting involvement in VPS13B-related pathways. RAB6A Protein, Human (His) is the recombinant human-derived RAB6A protein, expressed by E. coli , with N-His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
RAB6A protein forms a complex with BICD1 and directly interacts with DYNLRB1 in the GDP-bound state, suggesting a regulatory role in coordinating cellular functions. In the GTP-bound state, RAB6A interacts with VPS13B, suggesting involvement in VPS13B-related pathways. RAB6A Protein, Human (His) is the recombinant human-derived RAB6A protein, expressed by E. coli , with N-His labeled tag.
The RAB6A protein engages in specific interactions within cellular processes, forming a complex with BICD1 as evidenced by studies. Additionally, RAB6A demonstrates direct interaction with DYNLRB1 when in its GDP-bound state. This interaction suggests a regulatory role for RAB6A in coordinating cellular functions associated with DYNLRB1. Moreover, in its GTP-bound state, RAB6A interacts with VPS13B, indicating its involvement in molecular pathways associated with VPS13B. These interactions highlight the versatile nature of RAB6A in modulating various cellular processes and emphasize the need for further exploration to unravel the specific roles and regulatory mechanisms underlying these associations.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-His
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Accession
P20340-2 (M1-C208)
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Molecular Construction
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N-term
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His
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RAB6A (M1-C208)
Accession # P20340-2 -
C-term
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Protein Length
Full Length of Isoform-2
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Synonyms
RAB6A; RAB6, Member RAS Oncogene Family; Prev. RAB6; Rab GTPase; Ras-Related Protein Rab-6A; Rab-6; RAB6A, Member RAS Oncogene Family; Small Monomeric GTPase
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AA Sequence
MSTGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTIRLQLWDTAGQERFRSLIPSYIRDSAAAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSIEEGERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMESTQDRSREDMIDIKLEKPQEQPVSEGGCSC
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Molecular Weight
Approximately 26 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (235 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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