Serpin B12 Protein, Mouse (sf9, His)

Serpin B12 inhibits trypsin and plasmin but not thrombin, coagulation factor Xa, and urokinase-type plasminogen activator. Additionally, it interacts with SLFN12, contributing to cellular differentiation pathways, showcasing its multifunctional nature beyond classical protease inhibition. Serpin B12 Protein, Mouse (sf9, His) is the recombinant mouse-derived Serpin B12 protein, expressed by Sf9 insect cells , with C-His labeled tag.

Serpin B12, a versatile protease inhibitor, exerts inhibitory effects on trypsin and plasmin while sparing thrombin, coagulation factor Xa, and urokinase-type plasminogen activator. Beyond its role as a protease regulator, Serpin B12 is implicated in cell differentiation, where it interacts with SLFN12, contributing to a pathway that governs the intricate process of cellular differentiation. This highlights the multifunctional nature of Serpin B12, suggesting its involvement in crucial cellular processes beyond its classical role as a protease inhibitor.

Mouse

Sf9 insect cells

C-His

Q9D7P9 (M1-P423)

71869  [NCBI]

Full Length

MDSLTAANNKFCFDFFREISKDDAHKNIFVCPLSLSAAFGMVRLGARGDSAHQIDEALHFNELSKDEHKEPNDPSPQSESKASDSSLEGQKQTSASQDQQGESTNDHQLLGCHFGKLLSRIDRDKSYYTLSMANRLYGEQEFPICSEYSDDVTEFFHTTVESVDFQKDSEKSRQEINFWVESQSQGKIKELFGKEAIDNSTVLVLVNAVYFKAKWEREFNSENTVDASFCLNENEKKTVKMMNQKGKFRIGFIDELQAQILEMKYAMGKLSMLVLLPSCSEDNVNSLQELEKKINHEKLLAWSSSENLSEKPVAISFPQFNLEDSYDLKSILQDMGIKDVFDETKADLTGISKSPNLYLSKIVHKTFVEVDEMGTQAAAASGVVAAEKALPSWVEFNANHPFLFFIRHNPTQSLLFCGRVYCP

Approximately 58 kDa

≥ 80%, as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.22 μm filtered solution of 50 mM Tris,100 mM NaCl,0.5 mM PMSF, 10% glycerol, pH 7.4.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.