2. Recombinant Proteins
  3. Enzymes & Regulators
  4. Protease Inhibitors
  5. Serpin (Protease Inhibitor)
  6. Serpin B12
  7. Serpin B12 Protein, Mouse (sf9, His)

Serpin B12 Protein, Mouse (sf9, His)

Cat. No.: HY-P77197
Handling Instructions

Serpin B12 inhibits trypsin and plasmin but not thrombin, coagulation factor Xa, and urokinase-type plasminogen activator. Additionally, it interacts with SLFN12, contributing to cellular differentiation pathways, showcasing its multifunctional nature beyond classical protease inhibition. Serpin B12 Protein, Mouse (sf9, His) is the recombinant mouse-derived Serpin B12 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of Serpin B12 Protein, Mouse (sf9, His) is 423 a.a., with molecular weight of ~58 kDa.

For research use only. We do not sell to patients.

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Description

Serpin B12 inhibits trypsin and plasmin but not thrombin, coagulation factor Xa, and urokinase-type plasminogen activator. Additionally, it interacts with SLFN12, contributing to cellular differentiation pathways, showcasing its multifunctional nature beyond classical protease inhibition. Serpin B12 Protein, Mouse (sf9, His) is the recombinant mouse-derived Serpin B12 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of Serpin B12 Protein, Mouse (sf9, His) is 423 a.a., with molecular weight of ~58 kDa.
Background

Serpin B12, a versatile protease inhibitor, exerts inhibitory effects on trypsin and plasmin while sparing thrombin, coagulation factor Xa, and urokinase-type plasminogen activator. Beyond its role as a protease regulator, Serpin B12 is implicated in cell differentiation, where it interacts with SLFN12, contributing to a pathway that governs the intricate process of cellular differentiation. This highlights the multifunctional nature of Serpin B12, suggesting its involvement in crucial cellular processes beyond its classical role as a protease inhibitor.
Species

Mouse
Source

Sf9 insect cells
Tag

C-His
Accession

Q9D7P9 (M1-P423)
Gene ID

71869  [NCBI]
Molecular Construction
N-term
Serpin B12 (M1-P423)
Accession # Q9D7P9
His
C-term
Synonyms
SERPINB12; Serpin B12; Serine Protease Inhibitor-clade B12
Molecular Weight

Approximately 58 kDa
Purity

Greater than 90% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

Serpin B12 Protein, Mouse (sf9, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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