Serpin B12 Protein, Mouse (sf9, His)
Based on 1 Customer Validation
Serpin B12 inhibits trypsin and plasmin but not thrombin, coagulation factor Xa, and urokinase-type plasminogen activator. Additionally, it interacts with SLFN12, contributing to cellular differentiation pathways, showcasing its multifunctional nature beyond classical protease inhibition. Serpin B12 Protein, Mouse (sf9, His) is the recombinant mouse-derived Serpin B12 protein, expressed by Sf9 insect cells , with C-His labeled tag.
- Species: Mouse
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
Serpin B12 inhibits trypsin and plasmin but not thrombin, coagulation factor Xa, and urokinase-type plasminogen activator. Additionally, it interacts with SLFN12, contributing to cellular differentiation pathways, showcasing its multifunctional nature beyond classical protease inhibition. Serpin B12 Protein, Mouse (sf9, His) is the recombinant mouse-derived Serpin B12 protein, expressed by Sf9 insect cells , with C-His labeled tag.
Background
Serpin B12, a versatile protease inhibitor, exerts inhibitory effects on trypsin and plasmin while sparing thrombin, coagulation factor Xa, and urokinase-type plasminogen activator. Beyond its role as a protease regulator, Serpin B12 is implicated in cell differentiation, where it interacts with SLFN12, contributing to a pathway that governs the intricate process of cellular differentiation. This highlights the multifunctional nature of Serpin B12, suggesting its involvement in crucial cellular processes beyond its classical role as a protease inhibitor.
Technical Parameters
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Species Mouse
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Source Sf9 insect cells
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Tag C-His
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Accession
Q9D7P9 (M1-P423)
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Molecular Construction
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N-term
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Serpin B12 (M1-P423)
Accession # Q9D7P9 -
His
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C-term
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Protein Length
Full Length
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Synonyms
SERPINB12; Serpin B12; Serpin Family B Member 12; Yukopin; Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 12; SERPINB12 Protein; Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 12
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AA Sequence
MDSLTAANNKFCFDFFREISKDDAHKNIFVCPLSLSAAFGMVRLGARGDSAHQIDEALHFNELSKDEHKEPNDPSPQSESKASDSSLEGQKQTSASQDQQGESTNDHQLLGCHFGKLLSRIDRDKSYYTLSMANRLYGEQEFPICSEYSDDVTEFFHTTVESVDFQKDSEKSRQEINFWVESQSQGKIKELFGKEAIDNSTVLVLVNAVYFKAKWEREFNSENTVDASFCLNENEKKTVKMMNQKGKFRIGFIDELQAQILEMKYAMGKLSMLVLLPSCSEDNVNSLQELEKKINHEKLLAWSSSENLSEKPVAISFPQFNLEDSYDLKSILQDMGIKDVFDETKADLTGISKSPNLYLSKIVHKTFVEVDEMGTQAAAASGVVAAEKALPSWVEFNANHPFLFFIRHNPTQSLLFCGRVYCP
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Predicted Molecular Mass
49.3 kDa
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Molecular Weight
Approximately 58 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.22 μm filtered solution of 50 mM Tris,100 mM NaCl,0.5 mM PMSF, 10% glycerol, pH 7.4.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (237 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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