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SEZ6/BSRP-C Protein, Human (HEK293, His)

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SEZ6/BSRP-C protein is pivotal in cell-cell recognition and neuronal membrane signaling. It maintains balance in dendrite elongation and branching, crucial for complex dendritic arbor development. Additionally, SEZ6/BSRP-C is implicated in establishing proper excitatory synaptic connectivity, emphasizing its role in fundamental processes of neuronal development. SEZ6/BSRP-C Protein, Human (HEK293, His) is the recombinant human-derived SEZ6/BSRP-C protein, expressed by HEK293 , with C-His labeled tag.

For research use only. We do not sell to patients.
  • Species: Human
  • Source: HEK293
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
  • SEZ6/BSRP-C Protein, Human (HEK293, His) Product Image
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Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
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  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
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Biological Activity

Description

SEZ6/BSRP-C protein is pivotal in cell-cell recognition and neuronal membrane signaling. It maintains balance in dendrite elongation and branching, crucial for complex dendritic arbor development. Additionally, SEZ6/BSRP-C is implicated in establishing proper excitatory synaptic connectivity, emphasizing its role in fundamental processes of neuronal development. SEZ6/BSRP-C Protein, Human (HEK293, His) is the recombinant human-derived SEZ6/BSRP-C protein, expressed by HEK293 , with C-His labeled tag.

Background

SEZ6/BSRP-C protein appears to play a crucial role in cell-cell recognition and neuronal membrane signaling. Its significance lies in maintaining a delicate balance between dendrite elongation and branching, crucial for the intricate development of a complex dendritic arbor. Moreover, SEZ6/BSRP-C protein is implicated in the establishment of proper excitatory synaptic connectivity, emphasizing its involvement in fundamental processes underlying neuronal development.

Verified Bioactivity

1.Immobilized Human SEZ6, His Tag at 0.5 μg/mL (100 μL/well) on the plate. Dose response curve for Anti-SEZ6 Antibody, hFc Tag with the EC50 of 13.9 ng/mL determined by ELISA.
2.Immobilized Human SEZ6, His Tag at 1 μg/mL (100 μL/well) on the plate. Dose response curve for Anti-SEZ6 Antibody, hFc Tag with the EC50 of 1.0-10.0 ng/mL determined by ELISA.

Technical Parameters

  • Species Human
  • Source HEK293
  • Tag C-8*His
  • Accession

    Q53EL9-1 (L20-H925)

  • Gene ID
    124925  [NCBI]
  • Molecular Construction
    • N-term
    • SEZ6 (L20-H925)
      Accession # Q53EL9-1
    • 8*His
    • C-term
  • Protein Length

    Extracellular Domain

  • Synonyms

    SEZ6; HSEZ-6; Seizure Related 6 Homolog; BSRPC; Seizure Protein 6 Homolog; SEZ-6; Seizure Related 6 Homolog (Mouse)

  • AA Sequence

    LSLEAPTVGKGQAPGIEETDGELTAAPTPEQPERGVHFVTTAPTLKLLNHHPLLEEFLQEGLEKGDEELRPALPFQPDPPAPFTPSPLPRLANQDSRPVFTSPTPAMAAVPTQPQSKEGPWSPESESPMLRITAPLPPGPSMAVPTLGPGEIASTTPPSRAWTPTQEGPGDMGRPWVAEVVSQGAGIGIQGTITSSTASGDDEETTTTTTIITTTITTVQTPGPCSWNFSGPEGSLDSPTDLSSPTDVGLDCFFYISVYPGYGVEIKVQNISLREGETVTVEGLGGPDPLPLANQSFLLRGQVIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARFHCATGYQLKGARHLTCLNATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNLTCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPIEGLLSSGKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDPGYTLEQGSIIIECVDPHDPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDCIWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVTIQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCYPGYQVVGSSVLMCQWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYICDQGFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGARSPEKQLHPAGATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYNSRSLDVAKAPAASSTLDAAH

  • Predicted Molecular Mass

    98.9 kDa

  • Molecular Weight

    Approximately 130-180 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

  • Glycosylation

    Yes

  • Purity

    ≥ 95%, as determined by Bis-Tris PAGE.

Product Properties

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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