SLC20A2 Protein, Human (sf9, His, MBP, FLAG)

The SLC20A2 protein is a sodium-phosphate symporter that transports monovalent phosphate with a stoichiometry of two sodium ions per phosphate ion. Its role in bone mineralization is critical to bone quality and strength. SLC20A2 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC20A2 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.

SLC20A2, a sodium-phosphate symporter, demonstrates a preference for transporting the monovalent form of phosphate, with a stoichiometry of two sodium ions per phosphate ion. Documented in multiple studies, this transporter assumes a critical role in bone quality and strength by facilitating phosphate transport essential for bone mineralization. It is also vital for maintaining normal levels of phosphate in cerebrospinal fluid. Furthermore, SLC20A2 mediates phosphate-induced calcification of vascular smooth muscle cells and exhibits functional compensation for the loss of SLC20A1 in these cells. In the context of microbial infection, SLC20A2 serves as a retroviral receptor, rendering human cells susceptible to infection by amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV), and certain feline leukemia virus subgroup B (FeLV-B) variants. These multifaceted functions highlight the diverse roles of SLC20A2 in both physiological and pathological processes.

Human

Sf9 insect cells

N-MBP;C-Flag;N-8*His

Q08357 (A2-V652)

6575

Partial

AMDEYLWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYNETVETLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVGSTIGFSLVAIGTKGVQWMELVKIVASWFISPLLSGFMSGLLFVLIRIFILKKEDPVPNGLRALPVFYAATIAINVFSIMYTGAPVLGLVLPMWAIALISFGVALLFAFFVWLFVCPWMRRKITGKLQKEGALSRVSDESLSKVQEAESPVFKELPGAKANDDSTIPLTGAAGETLGTSEGTSAGSHPRAAYGRALSMTHGSVKSPISNGTFGFDGHTRSDGHVYHTVHKDSGLYKDLLHKIHIDRGPEEKPAQESNYRLLRRNNSYTCYTAAICGLPVHATFRAADSSAPEDSEKLVGDTVSYSKKRLRYDSYSSYCNAVAEAEIEAEEGGVEMKLASELADPDQPREDPAEEEKEEKDAPEVHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIYKQGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFSAAVMALLMYGILPYV

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.