SLC20A2 Protein, Human (sf9, His, MBP, FLAG)
The SLC20A2 protein is a sodium-phosphate symporter that transports monovalent phosphate with a stoichiometry of two sodium ions per phosphate ion. Its role in bone mineralization is critical to bone quality and strength. SLC20A2 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC20A2 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The SLC20A2 protein is a sodium-phosphate symporter that transports monovalent phosphate with a stoichiometry of two sodium ions per phosphate ion. Its role in bone mineralization is critical to bone quality and strength. SLC20A2 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC20A2 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
Background
SLC20A2, a sodium-phosphate symporter, demonstrates a preference for transporting the monovalent form of phosphate, with a stoichiometry of two sodium ions per phosphate ion. Documented in multiple studies, this transporter assumes a critical role in bone quality and strength by facilitating phosphate transport essential for bone mineralization. It is also vital for maintaining normal levels of phosphate in cerebrospinal fluid. Furthermore, SLC20A2 mediates phosphate-induced calcification of vascular smooth muscle cells and exhibits functional compensation for the loss of SLC20A1 in these cells. In the context of microbial infection, SLC20A2 serves as a retroviral receptor, rendering human cells susceptible to infection by amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV), and certain feline leukemia virus subgroup B (FeLV-B) variants. These multifaceted functions highlight the diverse roles of SLC20A2 in both physiological and pathological processes.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag N-MBP;C-Flag;N-8*His
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Accession
Q08357 (A2-V652)
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Gene ID6575
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Molecular Construction
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N-term
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8*His-MBP
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SLC20A2 (A2-V652)
Accession # Q08357 -
Flag
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C-term
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Protein Length
Full Length
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Synonyms
SLC20A2; Phosphate Transporter 2; Prev. GLVR2; Epididymis Secretory Sperm Binding Protein; Prev. MLVAR; Phosphate Transporter; Sodium-Dependent Phosphate Transporter 2; GLVR-2; PiT-2; IBGC1; PIT2; IBGC2; Gibbon Ape Leukemia Virus Receptor 2; IBGC3; Glvr-2
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AA Sequence
AMDEYLWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYNETVETLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVGSTIGFSLVAIGTKGVQWMELVKIVASWFISPLLSGFMSGLLFVLIRIFILKKEDPVPNGLRALPVFYAATIAINVFSIMYTGAPVLGLVLPMWAIALISFGVALLFAFFVWLFVCPWMRRKITGKLQKEGALSRVSDESLSKVQEAESPVFKELPGAKANDDSTIPLTGAAGETLGTSEGTSAGSHPRAAYGRALSMTHGSVKSPISNGTFGFDGHTRSDGHVYHTVHKDSGLYKDLLHKIHIDRGPEEKPAQESNYRLLRRNNSYTCYTAAICGLPVHATFRAADSSAPEDSEKLVGDTVSYSKKRLRYDSYSSYCNAVAEAEIEAEEGGVEMKLASELADPDQPREDPAEEEKEEKDAPEVHLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIYKQGGVTQEAATPVWLLFYGGVGICTGLWVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFVAWFVTVPVAGLFSAAVMALLMYGILPYV
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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