SLC30A10 Protein, Human (sf9, His, MBP, FLAG)
The SLC30A10 protein is a plasma membrane calcium:manganese antiporter that promotes the release of intracellular manganese and the simultaneous import of extracellular calcium. SLC30A10 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC30A10 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The SLC30A10 protein is a plasma membrane calcium:manganese antiporter that promotes the release of intracellular manganese and the simultaneous import of extracellular calcium. SLC30A10 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC30A10 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.
Background
SLC30A10 protein, a calcium:manganese antiporter localized in the plasma membrane, serves as a critical mediator for the efflux of intracellular manganese, operating in conjunction with an active extracellular calcium exchange. Essential for maintaining intracellular manganese homeostasis, this protein plays a crucial role in facilitating the proper functioning of enzymes vital for neurotransmitter metabolism and other neuronal metabolic pathways. Given manganese's dual role as an essential cofactor and potential cytotoxic agent inducing oxidative stress, mitochondrial dysfunction, and apoptosis, SLC30A10 emerges as a key regulator in balancing manganese levels within cells. Beyond its role in manganese transport, there is suggestive evidence indicating a potential intracellular zinc ion transporter activity for SLC30A10. This suggests a broader impact, as it may directly regulate intracellular zinc ion homeostasis, influencing various signaling pathways and biological processes.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag N-MBP;C-Flag;N-8*His
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Accession
Q6XR72 (G2-F485)
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Gene ID55532
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Molecular Construction
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N-term
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8*His-MBP
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SLC30A10 (G2-F485)
Accession # Q6XR72 -
Flag
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C-term
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Protein Length
Full Length
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Synonyms
SLC30A10; CDNA FLJ33487 Fis, Clone BRAMY2003538, Highly Similar To Homo Sapiens Solute Carrier Family 30, Member 10 (SLC30A10), Transcript Variant 1, MRNA; Solute Carrier Family 30 Member 10; Zinc Resistance Conferring Homolog (S. Cerevisiae); ZnT-10; Sol
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AA Sequence
GRYSGKTCRLLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDLISLCVGLSAGYIARRPTRGFSATYGYARAEVVGALSNAVFLTALCFTIFVEAVLRLARPERIDDPELVLIVGVLGLLVNVVGLLIFQDCAAWFACCLRGRSRRLQQRQQLAEGCVPGAFGGPQGAEDPRRAADPTAPGSDSAVTLRGTSVERKREKGATVFANVAGDSFNTQNEPEDMMKKEKKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVLPLKSEDPCNWQCYIDPSLTVLMVIIILSSAFPLIKETAAILLQMVPKGVNMEELMSKLSAVPGISSVHEVHIWELVSGKIIATLHIKYPKDRGYQDASTKIREIFHHAGIHNVTIQFENVDLKEPLEQKDLLLLCNSPCISKGCAKQLCCPPGALPLAHVNGCAEHNGGPSLDTYGSDGLSRRDAREVAIEVSLDSCLSDHGQSLNKTQEDQCYVNRTHF
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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