SLC30A10 Protein, Human (sf9, His, StrepⅡ, FLAG)

The SLC30A10 protein is a plasma membrane calcium:manganese antiporter that promotes the release of intracellular manganese and the simultaneous import of extracellular calcium. SLC30A10 Protein, Human (sf9, His, Strep, FLAG) is the recombinant human-derived SLC30A10 protein, expressed by sf9 insect cells , with N-Strep, C-Flag, N-8*His labeled tag.

SLC30A10 protein, a calcium:manganese antiporter localized in the plasma membrane, serves as a critical mediator for the efflux of intracellular manganese, operating in conjunction with an active extracellular calcium exchange. Essential for maintaining intracellular manganese homeostasis, this protein plays a crucial role in facilitating the proper functioning of enzymes vital for neurotransmitter metabolism and other neuronal metabolic pathways. Given manganese's dual role as an essential cofactor and potential cytotoxic agent inducing oxidative stress, mitochondrial dysfunction, and apoptosis, SLC30A10 emerges as a key regulator in balancing manganese levels within cells. Beyond its role in manganese transport, there is suggestive evidence indicating a potential intracellular zinc ion transporter activity for SLC30A10. This suggests a broader impact, as it may directly regulate intracellular zinc ion homeostasis, influencing various signaling pathways and biological processes.

Human

Sf9 insect cells

N-StrepⅡ;N-8*His;C-Flag

Q6XR72 (G2-F485)

55532

Partial

GRYSGKTCRLLFMLVLTVAFFVAELVSGYLGNSIALLSDSFNMLSDLISLCVGLSAGYIARRPTRGFSATYGYARAEVVGALSNAVFLTALCFTIFVEAVLRLARPERIDDPELVLIVGVLGLLVNVVGLLIFQDCAAWFACCLRGRSRRLQQRQQLAEGCVPGAFGGPQGAEDPRRAADPTAPGSDSAVTLRGTSVERKREKGATVFANVAGDSFNTQNEPEDMMKKEKKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVLPLKSEDPCNWQCYIDPSLTVLMVIIILSSAFPLIKETAAILLQMVPKGVNMEELMSKLSAVPGISSVHEVHIWELVSGKIIATLHIKYPKDRGYQDASTKIREIFHHAGIHNVTIQFENVDLKEPLEQKDLLLLCNSPCISKGCAKQLCCPPGALPLAHVNGCAEHNGGPSLDTYGSDGLSRRDAREVAIEVSLDSCLSDHGQSLNKTQEDQCYVNRTHF

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.