SLC30A2 Protein, Human (Sf9, His, MBP, FLAG)

The SLC30A2 protein acts as an electrically neutral proton-coupled antiporter, transporting zinc ions into various intracellular organelles. SLC30A2 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC30A2 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC30A2 Protein, Human (Sf9, His, MBP, FLAG) is 322 a.a., .

SLC30A2 Protein serves as an essential electroneutral proton-coupled antiporter, facilitating the concentration of zinc ions into various intracellular organelles, including endosomes, zymogen granules, and mitochondria. This pivotal function plays a crucial role in maintaining cellular zinc homeostasis, providing protection against the potential cytotoxic effects of excess zinc. In addition to its intracellular role, SLC30A2 regulates the zinc concentration in milk by transporting zinc ions into secretory vesicles of mammary cells. The protein's involvement in concentrating zinc ions into lysosomes is linked to lysosomal-mediated cell death during early mammary gland involution. Furthermore, SLC30A2 acts as an electroneutral proton-coupled antiporter that mediates the efflux of zinc ions through the plasma membrane, underscoring its multifaceted role in zinc transport across various cellular compartments.

Human

Sf9 insect cells

N-MBP;C-Flag;N-8*His

Q9BRI3 (E2-D323)

7780

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.