SLC30A3 Protein, Human (sf9, His, MBP, FLAG)

The SLC30A3 protein is a possible proton-coupled zinc antiporter that mediates cellular zinc homeostasis in the brain. It promotes zinc import into synaptic vesicles and regulates intracellular zinc levels, which are critical for neuronal processes. SLC30A3 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC30A3 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.

The SLC30A3 protein is identified as a probable proton-coupled zinc ion antiporter, playing a pivotal role in the cellular zinc ion homeostasis within the brain. Functioning as a mediator, it facilitates the import of zinc from the cytoplasm into synaptic vesicles, contributing to the regulation of intracellular zinc levels. This proton-coupled zinc ion antiporter activity suggests its involvement in maintaining the delicate balance of zinc ions, crucial for various cellular processes in neuronal environments. Further exploration of the precise mechanisms and regulatory functions of SLC30A3 in synaptic zinc transport will provide valuable insights into its role in neurophysiology and cellular homeostasis within the brain.

Human

Sf9 insect cells

N-MBP;C-Flag;N-8*His

Q99726 (E2-A388)

7781

Partial

EPSPAAGGLETTRLVSPRDRGGAGGSLRLKSLFTEPSEPLPEESKPVEMPFHHCHRDPLPPPGLTPERLHARRQLYAACAVCFVFMAGEVVGGYLAHSLAIMTDAAHLLADVGSMMGSLFSLWLSTRPATRTMTFGWHRSETLGALASVVSLWMVTGILLYLAFVRLLHSDYHIEGGAMLLTASIAVCANLLMAFVLHQAGPPHSHGSRGAEYAPLEEGPEEPLPLGNTSVRAAFVHVLGDLLQSFGVLAASILIYFKPQYKAADPISTFLFSICALGSTAPTLRDVLRILMEGTPRNVGFEPVRDTLLSVPGVRATHELHLWALTLTYHVASAHLAIDSTADPEAVLAEASSRLYSRFGFSSCTLQVEQYQPEMAQCLRCQEPPQA

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.