SLC40A1 Protein, Human (HEK293)
Based on 1 Customer Validation
SLC40A1 plays a pivotal role in systemic iron homeostasis by transporting Fe(2+) from cells to the bloodstream. Essential for maintaining iron balance, it enables dietary iron uptake, recycling by macrophages and erythrocytes, and controlled release from hepatocytes. In iron surplus, elevated HAMP/hepcidin levels prompt SLC40A1 degradation, limiting iron efflux into the plasma. SLC40A1 Protein, Human (HEK293) is the recombinant human-derived SLC40A1 protein, expressed by HEK293, with tag free.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
SLC40A1 plays a pivotal role in systemic iron homeostasis by transporting Fe(2+) from cells to the bloodstream. Essential for maintaining iron balance, it enables dietary iron uptake, recycling by macrophages and erythrocytes, and controlled release from hepatocytes. In iron surplus, elevated HAMP/hepcidin levels prompt SLC40A1 degradation, limiting iron efflux into the plasma. SLC40A1 Protein, Human (HEK293) is the recombinant human-derived SLC40A1 protein, expressed by HEK293, with tag free.
SLC40A1 emerges as a crucial player in systemic iron homeostasis by orchestrating the transportation of Fe(2+) from the intracellular milieu to the extracellular space. With a central role in maintaining the delicate balance of iron levels, SLC40A1 facilitates the transfer of iron from various cell types, including intestinal, splenic, hepatic cells, macrophages, and erythrocytes, into the bloodstream, ensuring a steady supply of iron to diverse tissues (By similarity). This multifaceted protein governs essential processes such as dietary iron uptake, recycling of iron by macrophages and erythrocytes, and the controlled release of iron stores in hepatocytes (By similarity). Notably, in conditions of iron surplus in the serum, elevated levels of circulating HAMP/hepcidin prompt the degradation of SLC40A1, thereby restricting the efflux of iron into the plasma.
Technical Parameters
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Species Human
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Source HEK293
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Tag Tag Free
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Accession
Q9NP59 (M1-V571)
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Gene ID30061
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Molecular Construction
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N-term
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SLC40A1 (M1-V571)
Accession # Q9NP59 -
C-term
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Protein Length
Full Length
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Synonyms
SLC40A1; Ferroportin; Prev. SLC11A3; Putative Ferroportin 1 Variant IIIB; IREG1; Putative Ferroportin 1 Variant IIIC; FPN1; Solute Carrier Family 40 Member; FPN; Iron-Regulated Transporter 1; HFE4; Ferroportin 1 Variant IIB; MTP1; Ferroportin 1 Variant I;
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AA Sequence
MTRAGDHNRQRGCCGSLADYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVFLHKHELLTMYHGWVLTSCYILIITIANIANLASTATAITIQRDWIVVVAGEDRSKLANMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYVLLWKVYQKTPALAVKAGLKEEETELKQLNLHKDTEPKPLEGTHLMGVKDSNIHELEHEQEPTCASQMAEPFRTFRDGWVSYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSILMGASAITGIMGTVAFTWLRRKCGLVRTGLISGLAQLSCLILCVISVFMPGSPLDLSVSPFEDIRSRFIQGESITPTKIPEITTEIYMSNGSNSANIVPETSPESVPIISVSLLFAGVIAARIGLWSFDLTVTQLLQENVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFVAMGHIMYFRFAQNTLGNKLFACGPDAKEVRKENQANTSVV
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Predicted Molecular Mass
55 kDa
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Molecular Weight
Approximately 55 kDa, based on SDS-PAGE under reducing conditions.
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Structure/Form
Monomer
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.22 μm filtered solution of 20 mM HEPES pH 7.5, 100 mM NaCl, 0.1% (w/v) DDM, and 0.01% (w/v) CHS, Protease inhibitor (Biortus).
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (239 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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