SLC51B Protein, Human (sf9, His, MBP, FLAG)

SLC51B emerges as an indispensable element within the Ost-alpha/Ost-beta complex, a dynamic heterodimer pivotal in facilitating bile acid export from enterocytes into the portal blood. This transporter duo, comprising Ost-alpha and Ost-beta, demonstrates remarkable efficacy in transporting various bile acids, with taurocholate being a prominent substrate. SLC51B's involvement extends beyond bile acid transport; it plays a crucial role in modulating the glycosylation, membrane trafficking, and stability of its partner SLC51A. The Ost-alpha/Ost-beta complex doesn't limit its repertoire to bile acids alone; it showcases versatility by efficiently transporting taurine-conjugated bile acids over their glycine-conjugated counterparts. Impressively, SLC51B exhibits proficiency in transporting steroids, including estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, thereby contributing to the enterohepatic circulation of sterols. Furthermore, its capacity to transport eicosanoids, such as prostaglandin E2, adds another layer to its multifaceted role in cellular transport processes.