SLC51B Protein, Human (Sf9, His, MBP, FLAG)

The SLC51B protein is an important component of the Ost-α/Ost-β complex, which transports bile acids from enterocytes to portal blood. SLC51B Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC51B protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC51B Protein, Human (Sf9, His, MBP, FLAG) is 127 a.a., .

SLC51B emerges as an indispensable element within the Ost-alpha/Ost-beta complex, a dynamic heterodimer pivotal in facilitating bile acid export from enterocytes into the portal blood. This transporter duo, comprising Ost-alpha and Ost-beta, demonstrates remarkable efficacy in transporting various bile acids, with taurocholate being a prominent substrate. SLC51B's involvement extends beyond bile acid transport; it plays a crucial role in modulating the glycosylation, membrane trafficking, and stability of its partner SLC51A. The Ost-alpha/Ost-beta complex doesn't limit its repertoire to bile acids alone; it showcases versatility by efficiently transporting taurine-conjugated bile acids over their glycine-conjugated counterparts. Impressively, SLC51B exhibits proficiency in transporting steroids, including estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, thereby contributing to the enterohepatic circulation of sterols. Furthermore, its capacity to transport eicosanoids, such as prostaglandin E2, adds another layer to its multifaceted role in cellular transport processes.

Human

Sf9 insect cells

N-MBP;C-Flag;N-8*His

Q86UW2 (G2-S128)

123264

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.