SPARC Protein, Cynomolgus (HEK293, His)

SPARC protein, crucial for regulating cell growth, interacts with the extracellular matrix and cytokines, exhibiting binding capabilities for calcium, copper, and various components like collagen types, albumin, thrombospondin, PDGF, and cell membranes. Notably, SPARC has two calcium binding sites—a low-affinity acidic domain binding 5 to 8 Ca(2+) ions, and a high-affinity EF-hand loop binding a Ca(2+) ion. These binding sites enable SPARC to effectively modulate cellular functions, contributing to cell growth regulation. SPARC Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived SPARC protein, expressed by HEK293, with C-His labeled tag. The total length of SPARC Protein, Cynomolgus (HEK293, His) is 286 a.a., with molecular weight of 43-48 kDa.

The SPARC protein plays a crucial role in regulating cell growth by interacting with the extracellular matrix and cytokines. It exhibits binding capabilities for calcium and copper, as well as various components such as different types of collagen, albumin, thrombospondin, PDGF, and cell membranes. Notably, SPARC possesses two calcium binding sites. The acidic domain binds 5 to 8 Ca(2+) ions with low affinity, while the EF-hand loop binds a Ca(2+) ion with high affinity. These binding sites enable SPARC to effectively modulate cellular functions and contribute to the regulation of cell growth.

Cynomolgus

HEK293

C-His

G7P8R2 (A18-I303)

101925878  [NCBI]

43-48 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.