TIM-1/KIM-1/HAVCR Protein, Rhesus Macaque (116a.a, HEK293, His)

TIM-1, a key member and costimulatory molecule in the T cell immunoglobulin mucin (TIM) family, is expressed on the surface of T cells. TIM-1 gene mutations in human and mouse are associated with some allergic diseases. Abnormal expression of TIM-1 is related to some autoimmune diseases. TIM-1 is mainly expressed on the surfaces of CD4+ T cells, CD8+ T cells, NK cells, macrophages, DCs, B cells, and mast cells. Moreover, it is also found that TIM-1 is expressed in lymphoid tissues and confirmed that TIM-1 can promote the production of cytokines and enhance the antigen induced immune response of T cells. TIM-1, a new costimulatory candidate molecule for tumor treatment, not only directly enhances the antitumor effect of CD8+ T cells and NK cells but also changes the tumor microenvironment to induce more effective antitumor immune response. Type 1 immune response of TIM-1-mediated T cell activation is associated with tumor immunity through transcription factor T-bet/Eomes and the PI3K signal pathway. As a target molecule, it may have a good application prospect in clinical cancer research. In addition, agonistic anti-TIM-1 monoclonal antibody or other ligands can enhance the function of T cells, increase CD8+ T cells and NK cells, reduce MDSC in tumor tissues, and inhibit tumor growth^[1].