TREML2 Protein, Mouse (HEK293, His)
TREML2 protein acts as a cell surface receptor for SEMA6A and affects key intercellular signaling in cerebellar development. It regulates granule cell migration, coordinates actin cytoskeletal reorganization, and contributes significantly to axonal guidance in the central nervous system. TREML2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TREML2 protein, expressed by HEK293 , with C-6*His labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
TREML2 protein acts as a cell surface receptor for SEMA6A and affects key intercellular signaling in cerebellar development. It regulates granule cell migration, coordinates actin cytoskeletal reorganization, and contributes significantly to axonal guidance in the central nervous system. TREML2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TREML2 protein, expressed by HEK293 , with C-6*His labeled tag.
Background
Semaphorin-6A/SEMA6A serves as a cell surface receptor for PLXNA2 and plays a crucial role in cell-cell signaling, particularly in the regulation of granule cell migration during cerebellar development. It orchestrates the reorganization of the actin cytoskeleton and functions as a significant contributor to axon guidance within the developing central nervous system, exhibiting repulsive action towards migrating granular neurons. Additionally, SEMA6A is implicated in channeling sympathetic axons into sympathetic chains and controlling the temporal sequence of sympathetic target innervation. In the context of microbial infection, SEMA6A acts as a receptor for P.sordellii toxin TcsL in the vascular system, underscoring its diverse roles in both developmental processes and response to external stimuli.
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-6*His
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Accession
Q2LA85 (H25-A270)
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Molecular Construction
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N-term
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TREML2 (H25-A270)
Accession # Q2LA85 -
6*His
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C-term
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Protein Length
Extracellular Domain
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Synonyms
TREML2; Trem-Like Transcript 2 Protein; Prev. C6orf76; TLT-2; TLT2; Triggering Receptor Expressed On Myeloid Cells-Like 2; DJ238O23.1; Chromosome 6 Open Reading Frame 76; Triggering Receptor Expressed On Myeloid Cells-Like Protein 2; TREM-Like Transcript
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AA Sequence
HSNENLYRKVWRREGETLSVQCSYKNRRNLVEAKSWCKVKKKKCDHNFTRSWVRGPSYSLRDDAKVKVVRITMEALRVQDSGRYWCMRNTAGHFYPLVGFQLEVYPALTTERNVPHTHLTNTPMDGFVTTGQVHISDPHAPFTSDVTMFTSEVTMFTSGLLTLASGTTTPTPVTGYSFIDTSGTVTEPERNTESQPATLSPSNARSFSADPVTTSTMSRHQSSSLSTTGTCHPLTPNRSQETYIPA
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Predicted Molecular Mass
28.4 kDa
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Molecular Weight
Approximately 58-62 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US;may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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