TREML2 Protein, Mouse (HEK293, His)

TREML2 protein acts as a cell surface receptor for SEMA6A and affects key intercellular signaling in cerebellar development. It regulates granule cell migration, coordinates actin cytoskeletal reorganization, and contributes significantly to axonal guidance in the central nervous system. TREML2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TREML2 protein, expressed by HEK293 , with C-6*His labeled tag.

Semaphorin-6A/SEMA6A serves as a cell surface receptor for PLXNA2 and plays a crucial role in cell-cell signaling, particularly in the regulation of granule cell migration during cerebellar development. It orchestrates the reorganization of the actin cytoskeleton and functions as a significant contributor to axon guidance within the developing central nervous system, exhibiting repulsive action towards migrating granular neurons. Additionally, SEMA6A is implicated in channeling sympathetic axons into sympathetic chains and controlling the temporal sequence of sympathetic target innervation. In the context of microbial infection, SEMA6A acts as a receptor for P.sordellii toxin TcsL in the vascular system, underscoring its diverse roles in both developmental processes and response to external stimuli.

Mouse

HEK293

C-6*His

Q2LA85 (H25-A270)

328833  [NCBI]

Extracellular Domain

HSNENLYRKVWRREGETLSVQCSYKNRRNLVEAKSWCKVKKKKCDHNFTRSWVRGPSYSLRDDAKVKVVRITMEALRVQDSGRYWCMRNTAGHFYPLVGFQLEVYPALTTERNVPHTHLTNTPMDGFVTTGQVHISDPHAPFTSDVTMFTSEVTMFTSGLLTLASGTTTPTPVTGYSFIDTSGTVTEPERNTESQPATLSPSNARSFSADPVTTSTMSRHQSSSLSTTGTCHPLTPNRSQETYIPA

Approximately 58-62 kDa, based on SDS-PAGE under reducing conditions.

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.